STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1397342aa long hypothetical deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (342 aa)    
Predicted Functional Partners:
PH1381
138aa long hypothetical translation initiation factor eIF-5a; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
   
 0.999
PH1563
301aa long hypothetical typeII DNA topoisomerase subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family.
     
 0.883
PH0052
227aa long hypothetical fibrillarin-like pre-rRNA processing protein; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
  
  
 0.725
PH1602
871aa long hypothetical protein; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.
 
   
 0.684
PH0633
181aa long hypothetical ubiquinol-cytochrome c reductase complex subunit VI; Similar to PIR:G64367 percent identity: 54.717 in 159aa; owl:EGHUMSIM percent identity: 45.513 in 159aa; owl:AF013804 percent identity: 42.675 in 160aa; Belongs to the universal ribosomal protein uL16 family.
 
    0.665
PH0664
110aa long hypothetical transcription-associated protein; Similar to PIR:A55263 percent identity: 65.138 in 110aa; PIR:C64443 percent identity: 47.222 in 110aa. motif=TFIIS zinc ribbon domain signature; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
  
 
 0.647
PH0658
499aa long hypothetical phenylalanyl-tRNA synthetase subunit alpha chain; Similar to PIR:G64360 percent identity: 41.837 in 411aa; owl:SS56KBFR21 percent identity: 38.829 in 495aa; owl:CH19HHR234 percent identity: 42.907 in 297aa. motif=aminoacyl-transfer RNA synthetases class-II signatures; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
  
  
 0.615
PH1401
203aa long hypothetical protein; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family.
 
     0.583
PH1399
Similar to PIR:A64403 percent identity: 40.659 in 189aa. motif=FKBP-type peptidyl-prolyl cis-trans isomerase signatures/profile.
  
    0.581
PH1641
148aa long hypothetical 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family.
 
    0.566
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.