Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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PH0092821aa long hypothetical phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (821 aa)    
Predicted Functional Partners:
PH0570
478aa long hypothetical pyruvate kinase; Similar to PIR:A57418 percent identity:76.037 in 217aa; PIR:S76677 percent identity:42.128 in 484aa; Swiss_Prot:Q02499 percent identity:43.991 in 475aa. motif=eukaryotic thiol (cysteine) proteases active sites; Belongs to the pyruvate kinase family.
   
 0.981
PH1942
428aa long hypothetical phosphoglycerate dehydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
 0.971
PH0834
571aa long hypothetical oxaloacetate decarboxylase alpha chain; Similar to PIR:F64453 percent identity: 56.150 in 571aa; owl:LPOADAGEN percent identity: 47.518 in 593aa; Swiss_Prot:Q03030 percent identity: 46.032 in 590aa. motif=biotin-requiring enzymes attachment site.
   
 
 0.956
PH1275
439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme]; Similar to owl:AF008220168 percent identity: 51.621 in 415aa; Swiss_Prot:P16468 percent identity: 55.795 in 384aa; owl:SBU35659 percent identity: 54.885 in 360aa. motif=malic enzymes signature.
    
 0.943
PH0016
475aa long hypothetical protein; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family.
     
 0.942
PH0682
108aa long hypothetical ferredoxin oxidoreductase delta subunit; Similar to owl:PFPORVOR9 percent identity: 95.238 in 105aa; owl:PFPORVOR6 percent identity: 62.667 in 75aa; PIR:E64333 percent identity: 58.824 in 85aa. motif=4Fe-4S ferredoxins, iron-sulfur binding region signature.
    
 0.941
PH0678
185aa long hypothetical ferredoxin oxidoreductase gamma subunit; Similar to owl:PFPORVOR5 percent identity: 90.270 in 185aa; PIR:F64333 percent identity: 65.698 in 179aa; owl:TMPMRFDNA2 percent identity: 44.000 in 177aa.
  
 
 0.919
PH1630
341aa long hypothetical protein.
    
 0.916
PH0312
621aa long hypothetical phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
     
 0.914
PH0759
390aa long hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
   
 
 0.913
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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