Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PH0216296aa long hypothetical protein. (296 aa)    
Predicted Functional Partners:
PH0258
168aa long hypothetical protein.
       0.671
PH0286
899aa long hypothetical protein; Similar to PIR:H64494 percent identity: 33.876 in 312aa. motif=ATP/GTP-binding site motif A (P-loop).
       0.671
PH0287
787aa long hypothetical protein; Similar to PIR:A64495 percent identity: 36.842 in 365aa.
       0.671
PH0343
170aa long hypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.
       0.671
PH1074
277aa long hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates (GTP,UTP) as well as inorganic polyphosphate (poly(P)) as a source of phosphorus. NAD is the preferred substrate for the kinase, but NADH can also be used as phosphoryl acceptor.
       0.671
PH1989
335aa long hypothetical protein; Similar to PIR:B64499 percent identity: 25.316 in 325aa.
       0.671
PH1991
389aa long hypothetical nucleolar protein; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs. This modification appears to slightly promote the thermal stability of P.horikoshii tRNAs, but does not affect their amino acid accepting activity. Four elements in the acceptor stems of tRNAs are essential for substrate recognition by this enzyme: the target site C72, the 3'-CCA terminus, U73 or G73, and the second base pair C2:G71.
       0.671
PH0289
169aa long hypothetical protein; Similar to PIR:B64495 percent identity:36.170 in 94aa; Belongs to the GbsR family.
       0.605
PH0303
484aa long hypothetical protein.
       0.580
PH0056
230aa long hypothetical HESA protein; Similar to Swiss_Prot:P46048 percent identity: 44.037 in 223aa; Swiss_Prot:P18500 percent identity: 41.872 in 206aa; PIR:A49890 percent identity: 39.450 in 223aa.
       0.576
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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