STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH0435340aa long hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (340 aa)    
Predicted Functional Partners:
PH1987
324aa long hypothetical O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
  
 
 0.877
PH1465
650aa long hypothetical protein; Similar to PIR:H64502 percent identity: 40.689 in 678aa.
     0.872
PH1654
427aa long hypothetical serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.863
PH0434
336aa long hypothetical protein; Similar to PIR:H64446 percent identity: 32.530 in 348aa.
  
  
 0.796
PH0436
452aa long hypothetical protein; Similar to PIR:D64510 percent identity: 43.458 in 448aa; owl:TSPGLU percent identity: 41.994 in 349aa. motif=ATP/GTP-binding site motif A (P-loop).
       0.752
PH1116
582aa long hypothetical protein; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
     
 0.711
PH0897
773aa long hypothetical transcriptional regulatory protein hypF; Similar to PIR:A64389 percent identity: 48.027 in 759aa; owl:MMU472747 percent identity: 50.278 in 552aa; PIR:S76302 percent identity: 36.474 in 765aa. motif=ATP/GTP-binding site motif A (P-loop).
      
 0.683
PH1731
198aa long hypothetical protein; Similar to PIR:H64415 percent identity: 44.974 in 197aa. motif=N-6 Adenine-specific DNA methylases signature.
  
  
 0.663
PH0445
219aa long hypothetical protein; Similar to PIR:A64441 percent identity: 42.458 in 187aa. motif=protein kinases signatures and profile.
  
  
 0.655
PH0413
356aa long hypothetical glucose-1-phosphate thymidylyltransferase; Similar to owl:SAMTMDE percent identity: 53.890 in 352aa; Swiss_Prot:P08075 percent identity: 50.720 in 352aa; PIR:S76366 percent identity: 51.143 in 358aa.
      0.629
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.