STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH0442560aa long hypothetical protein; Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily. (560 aa)    
Predicted Functional Partners:
PH0439
255aa long hypothetical competence-damage protein; Similar to owl:SS56KBFR18 percent identity: 45.455 in 219aa; owl:D908567 percent identity: 38.953 in 180aa; owl:BSU877925 percent identity: 37.222 in 188aa; Belongs to the CinA family.
       0.779
PH0440
276aa long hypothetical translation initiation factor eIF-2B; Catalyzes the exchange of initiation factor 2-bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family.
       0.773
PH0438
339aa long hypothetical adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
       0.711
PH1640
180aa long hypothetical 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
    
   0.642
PH1773
155aa long hypothetical 50S ribosomal protein L22; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
 
 
   0.610
PH1775
239aa long hypothetical 50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
 
 
   0.582
PH1755
150aa long hypothetical 50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
  
 
   0.577
PH0058
158aa long hypothetical 40S ribosomal protein S13; Similar to Swiss_Prot:P54012 percent identity: 70.667 in 157aa; Swiss_Prot:Q05761 percent identity: 50.000 in 157aa; Swiss_Prot:P49203 percent identity: 48.649 in 155aa. motif=ribosomal protein S15 signature.
   
   0.556
PH0059
478aa long hypothetical protein; Similar to PIR:A64422 percent identity: 31.655 in 439aa; PIR:G64403 percent identity: 36.567 in 449aa.
     
 0.541
PH0044
855aa long hypothetical protein; Similar to PIR:H64474 percent identity: 44.305 in 827aa.
  
     0.536
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.