STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH0716296aa long hypothetical protein. (296 aa)    
Predicted Functional Partners:
PH0717
395aa long hypothetical protein.
       0.773
PH0718
398aa long hypothetical protein; Similar to PIR:D64464 percent identity: 41.848 in 385aa.
     
 0.725
PH1155
446aa long hypothetical thiamine biosynthesis protein; Similar to Swiss_Prot:P44697 percent identity: 51.538 in 267aa; owl:HPAE0005959 percent identity: 44.531 in 262aa; owl:MTCY22G1018 percent identity: 44.980 in 254aa.
 
  
0.647
PH1156
161aa long hypothetical thiamine biosynthetic bifunctional protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
    
 0.610
PH0057
168aa long hypothetical protein; Similar to owl:HPAE00058613 percent identity: 43.312 in 160aa; owl:MTCY1A1020 percent identity: 48.696 in 115aa; owl:MLCL58110 percent identity: 45.082 in 122aa. motif=zinc carboxypeptidases, zinc-binding regions signatures.
 
      0.594
PH0720
308aa long hypothetical aspartate carbamoyltransferase catalytic chain; Similar to owl:PAU61765 percent identity: 92.532 in 308aa; PIR:D64497 percent identity: 58.503 in 297aa; owl:VSPYRBI1 percent identity: 55.593 in 302aa. motif=aspartate and ornithine carbamoyltransferases signature.
       0.528
PH0721
152aa long hypothetical aspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase.
       0.528
PH1357
255aa long hypothetical thiamine biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
 
   
 0.464
PH0619
197aa long hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexe [...]
  
     0.439
PH1827
301aa long hypothetical protein; Similar to PIR:A64421 percent identity:31.923 in 273aa.
 
     0.414
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.