PH0857 protein (Pyrococcus horikoshii) - STRING interaction network

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PH0857

394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (394 aa)

Predicted Functional Partners:

PH1087

0.985

PH1627

0.911

PH1406

0.909

PH0655

0.907

PH1075

0.862

PH0858

0.803

PH1086

0.691

PH1724

0.686

PH1221

0.610

PH1355

0.605

Your Current Organism:

Pyrococcus horikoshii

NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PH0655	PH0857	gene:9377599	gene:9377808	348aa long hypothetical dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate. Is much less efficient when using NADP(+) instead of NAD(+). To a lesser extent, also catalyzes the oxidation of L-serine and DL-threo-3- phenylserine, but not that of L-allo-threonine, D-threonine and D-allo- threonine and many other L-amino acids.	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	0.907
PH0655	PH1355	gene:9377599	gene:9378331	348aa long hypothetical dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate. Is much less efficient when using NADP(+) instead of NAD(+). To a lesser extent, also catalyzes the oxidation of L-serine and DL-threo-3- phenylserine, but not that of L-allo-threonine, D-threonine and D-allo- threonine and many other L-amino acids.	335aa long hypothetical ethylene-responsive protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.	0.656
PH0655	PH1406	gene:9377599	gene:9378382	348aa long hypothetical dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate. Is much less efficient when using NADP(+) instead of NAD(+). To a lesser extent, also catalyzes the oxidation of L-serine and DL-threo-3- phenylserine, but not that of L-allo-threonine, D-threonine and D-allo- threonine and many other L-amino acids.	440aa long hypothetical threonine synthase; Similar to PIR:H64482 percent identity: 41.525 in 374aa; Swiss_Prot:Q10610 percent identity: 35.254 in 303aa; Swiss_Prot:P45837 percent identity: 34.915 in 303aa.	0.907
PH0655	PH1627	gene:9377599	gene:9378617	348aa long hypothetical dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate. Is much less efficient when using NADP(+) instead of NAD(+). To a lesser extent, also catalyzes the oxidation of L-serine and DL-threo-3- phenylserine, but not that of L-allo-threonine, D-threonine and D-allo- threonine and many other L-amino acids.	346aa long hypothetical threonine synthase; Similar to PIR:H64482 percent identity: 36.111 in 357aa.	0.907
PH0857	PH0655	gene:9377808	gene:9377599	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	348aa long hypothetical dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate. Is much less efficient when using NADP(+) instead of NAD(+). To a lesser extent, also catalyzes the oxidation of L-serine and DL-threo-3- phenylserine, but not that of L-allo-threonine, D-threonine and D-allo- threonine and many other L-amino acids.	0.907
PH0857	PH0858	gene:9377808	gene:9377809	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	359aa long hypothetical protein; Similar to PIR:C64371 percent identity:43.558 in 169aa. motif=aspartokinase signature; Belongs to the aspartokinase family.	0.803
PH0857	PH1075	gene:9377808	gene:9378034	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	319aa long hypothetical homoserine dehydrogenase; Similar to PIR:A64500 percent identity: 34.967 in 329aa.	0.862
PH0857	PH1086	gene:9377808	gene:9378045	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	346aa long hypothetical aspartokinase; Similar to Swiss_Prot:P26512 percent identity:34.375 in 130aa; PIR:C64371 percent identity:35.948 in 157aa; OWL:TTHASKAB percent identity:32.308 in 131aa. motif=aspartokinase signature.	0.691
PH0857	PH1087	gene:9377808	gene:9378046	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	271aa long hypothetical homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.	0.985
PH0857	PH1221	gene:9377808	gene:9378183	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	138aa long hypothetical protein.	0.610
PH0857	PH1355	gene:9377808	gene:9378331	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	335aa long hypothetical ethylene-responsive protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.	0.605
PH0857	PH1406	gene:9377808	gene:9378382	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	440aa long hypothetical threonine synthase; Similar to PIR:H64482 percent identity: 41.525 in 374aa; Swiss_Prot:Q10610 percent identity: 35.254 in 303aa; Swiss_Prot:P45837 percent identity: 34.915 in 303aa.	0.909
PH0857	PH1627	gene:9377808	gene:9378617	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	346aa long hypothetical threonine synthase; Similar to PIR:H64482 percent identity: 36.111 in 357aa.	0.911
PH0857	PH1724	gene:9377808	gene:9378720	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	163aa long hypothetical 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.	0.686
PH0858	PH0857	gene:9377809	gene:9377808	359aa long hypothetical protein; Similar to PIR:C64371 percent identity:43.558 in 169aa. motif=aspartokinase signature; Belongs to the aspartokinase family.	394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	0.803
PH0858	PH1075	gene:9377809	gene:9378034	359aa long hypothetical protein; Similar to PIR:C64371 percent identity:43.558 in 169aa. motif=aspartokinase signature; Belongs to the aspartokinase family.	319aa long hypothetical homoserine dehydrogenase; Similar to PIR:A64500 percent identity: 34.967 in 329aa.	0.979
PH0858	PH1086	gene:9377809	gene:9378045	359aa long hypothetical protein; Similar to PIR:C64371 percent identity:43.558 in 169aa. motif=aspartokinase signature; Belongs to the aspartokinase family.	346aa long hypothetical aspartokinase; Similar to Swiss_Prot:P26512 percent identity:34.375 in 130aa; PIR:C64371 percent identity:35.948 in 157aa; OWL:TTHASKAB percent identity:32.308 in 131aa. motif=aspartokinase signature.	0.908
PH0858	PH1087	gene:9377809	gene:9378046	359aa long hypothetical protein; Similar to PIR:C64371 percent identity:43.558 in 169aa. motif=aspartokinase signature; Belongs to the aspartokinase family.	271aa long hypothetical homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.	0.852
PH0858	PH1406	gene:9377809	gene:9378382	359aa long hypothetical protein; Similar to PIR:C64371 percent identity:43.558 in 169aa. motif=aspartokinase signature; Belongs to the aspartokinase family.	440aa long hypothetical threonine synthase; Similar to PIR:H64482 percent identity: 41.525 in 374aa; Swiss_Prot:Q10610 percent identity: 35.254 in 303aa; Swiss_Prot:P45837 percent identity: 34.915 in 303aa.	0.667
PH0858	PH1627	gene:9377809	gene:9378617	359aa long hypothetical protein; Similar to PIR:C64371 percent identity:43.558 in 169aa. motif=aspartokinase signature; Belongs to the aspartokinase family.	346aa long hypothetical threonine synthase; Similar to PIR:H64482 percent identity: 36.111 in 357aa.	0.667

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