STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH0928442aa long hypothetical protein. (442 aa)    
Predicted Functional Partners:
PH0932
555aa long hypothetical protein; Similar to PIR:D64478 percent identity: 41.295 in 463aa; PIR:H64510 percent identity: 35.743 in 533aa; PIR:D64495 percent identity: 39.378 in 436aa. motif=ATP/GTP-binding site motif A (P-loop); gram-positive cocci surface proteins 'anchoring' hexapeptide.
   
 
 0.936
PH0929
879aa long hypothetical purine NTPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily.
     
 0.824
PH0263
529aa long hypothetical DNA repair protein; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity).
     
 0.820
PH1280
715aa long hypothetical protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
      
 0.816
PH0930
413aa long hypothetical protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
     
 0.789
PH1328
124aa long hypothetical protein; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family.
     
 0.770
PH0044
855aa long hypothetical protein; Similar to PIR:H64474 percent identity: 44.305 in 827aa.
      
 0.769
PH0934
390aa long hypothetical Na(+)/H(+) antiporter; Similar to Swiss_Prot:P26235 percent identity: 29.894 in 391aa; owl:BMU17283 percent identity: 29.630 in 391aa; owl:LLUPP percent identity: 26.133 in 389aa.
       0.654
PHS029
69aa long hypothetical protein; Similar to PIR:H64501 percent identity: 58.140 in 44aa.
       0.654
PH0935
246aa long hypothetical protein; Similar to PIR:D64479 percent identity:30.625 in 162aa.
       0.483
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.