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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH0951283aa long hypothetical 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (283 aa)    
Predicted Functional Partners:
PH1390
301aa long hypothetical thiamin biosynthesis protein; Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid.
   
 0.997
PH1807
463aa long hypothetical DNA damage-inducible protein; Similar to PIR:JC4561 percent identity: 76.944 in 362aa; PIR:JC4562 percent identity: 82.796 in 93aa; owl:HPAE0005886 percent identity: 32.800 in 382aa. motif=crystallins beta and gamma 'Greek key' motif signature.
  
  
 0.833
PH0011
283aa long hypothetical nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
      0.810
PH0159
162aa long hypothetical protein; Probable biotin transporter; Belongs to the BioY family.
     
 0.803
PH1609
158aa long hypothetical protein; Similar to PIR:E64339 percent identity: 46.980 in 152aa; Belongs to the PdaD family.
      
 0.769
PH1444
401aa long hypothetical protein DFP; Similar to PIR:A64414 percent identity: 42.159 in 405aa; Swiss_Prot:P44953 percent identity: 36.579 in 400aa; Swiss_Prot:P24285 percent identity: 33.509 in 403aa.
 
   
 0.688
PH0952
753aa long hypothetical protein; motif=ATP/GTP-binding site motif A (P-loop).
  
    0.686
PH1602
871aa long hypothetical protein; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.
       0.654
PH0147
235aa long hypothetical biotin--[acetyl-CoA-carboxylase] ligase; Similar to Swiss_Prot:P42975 percent identity: 36.245 in 250aa; owl:BSU20445 percent identity: 36.245 in 250aa.
  
  
 0.557
PH1347
308aa long hypothetical GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.552
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.