PH1059 protein (Pyrococcus horikoshii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PH1059

141aa long hypothetical protein; Similar to PIR:G64325 percent identity: 50.820 in 122aa. (141 aa)

Predicted Functional Partners:

PH0619

0.672

PH1002

0.608

PH1601

0.587

PH0783

0.532

PH0620

0.478

PH0117

0.465

PH0532

0.464

PH1948

0.458

PHS053

0.444

PH1543

0.440

Your Current Organism:

Pyrococcus horikoshii

NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PH0117	PH0783	gene:9377025	gene:9377732	472aa long hypothetical protein; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.	200aa long hypothetical protein.	0.450
PH0117	PH1059	gene:9377025	gene:9378017	472aa long hypothetical protein; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.	141aa long hypothetical protein; Similar to PIR:G64325 percent identity: 50.820 in 122aa.	0.465
PH0117	PH1543	gene:9377025	gene:9378528	472aa long hypothetical protein; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.	145aa long hypothetical transcription termination-antitermination factor nusA; Participates in transcription termination. Belongs to the NusA family.	0.418
PH0532	PH1059	gene:9377467	gene:9378017	117aa long hypothetical protein; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity); Belongs to the prefoldin subunit beta family.	141aa long hypothetical protein; Similar to PIR:G64325 percent identity: 50.820 in 122aa.	0.464
PH0532	PH1543	gene:9377467	gene:9378528	117aa long hypothetical protein; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity); Belongs to the prefoldin subunit beta family.	145aa long hypothetical transcription termination-antitermination factor nusA; Participates in transcription termination. Belongs to the NusA family.	0.621
PH0619	PH0620	gene:9377560	gene:9377562	197aa long hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexe [...]	664aa long hypothetical protein.	0.558
PH0619	PH0783	gene:9377560	gene:9377732	197aa long hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexe [...]	200aa long hypothetical protein.	0.624
PH0619	PH1059	gene:9377560	gene:9378017	197aa long hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexe [...]	141aa long hypothetical protein; Similar to PIR:G64325 percent identity: 50.820 in 122aa.	0.672
PH0619	PH1543	gene:9377560	gene:9378528	197aa long hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexe [...]	145aa long hypothetical transcription termination-antitermination factor nusA; Participates in transcription termination. Belongs to the NusA family.	0.630
PH0619	PH1601	gene:9377560	gene:9378591	197aa long hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexe [...]	120aa long hypothetical protein; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Binds RNase P RNA.	0.517
PH0620	PH0619	gene:9377562	gene:9377560	664aa long hypothetical protein.	197aa long hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexe [...]	0.558
PH0620	PH0783	gene:9377562	gene:9377732	664aa long hypothetical protein.	200aa long hypothetical protein.	0.647
PH0620	PH1059	gene:9377562	gene:9378017	664aa long hypothetical protein.	141aa long hypothetical protein; Similar to PIR:G64325 percent identity: 50.820 in 122aa.	0.478
PH0620	PH1543	gene:9377562	gene:9378528	664aa long hypothetical protein.	145aa long hypothetical transcription termination-antitermination factor nusA; Participates in transcription termination. Belongs to the NusA family.	0.533
PH0783	PH0117	gene:9377732	gene:9377025	200aa long hypothetical protein.	472aa long hypothetical protein; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.	0.450
PH0783	PH0619	gene:9377732	gene:9377560	200aa long hypothetical protein.	197aa long hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexe [...]	0.624
PH0783	PH0620	gene:9377732	gene:9377562	200aa long hypothetical protein.	664aa long hypothetical protein.	0.647
PH0783	PH1059	gene:9377732	gene:9378017	200aa long hypothetical protein.	141aa long hypothetical protein; Similar to PIR:G64325 percent identity: 50.820 in 122aa.	0.532
PH0783	PH1543	gene:9377732	gene:9378528	200aa long hypothetical protein.	145aa long hypothetical transcription termination-antitermination factor nusA; Participates in transcription termination. Belongs to the NusA family.	0.447
PH0783	PHS053	gene:9377732	gene:9378843	200aa long hypothetical protein.	93aa long hypothetical protein; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family.	0.441

page 1 of 3

Server load: low (30%) [HD]

Permalink

Network

Neighborhood

Textmining

Cooccurrence

Experiments

Coexpression

Databases

Fusion

© STRING Consortium 2025

Credits

Access

Info

About