STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1221138aa long hypothetical protein. (138 aa)    
Predicted Functional Partners:
PH1726
380aa long hypothetical isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.945
PH1722
323aa long hypothetical 3-isopropylmalate dehydrogenase; May play a dual role in glutamate and lysine biosynthesis in vivo. Uses isocitrate and homoisocitrate at near equal efficiency and preferentially uses NAD over NADP.
  
 
 0.943
PH1724
163aa long hypothetical 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
  
 0.935
PH1727
361aa long hypothetical 2-isopropylmalate synthase; Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.
  
  
 0.903
PH1075
319aa long hypothetical homoserine dehydrogenase; Similar to PIR:A64500 percent identity: 34.967 in 329aa.
  
  
 0.895
PH1087
271aa long hypothetical homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
  
 0.656
PH1387
307aa long hypothetical phosphoglycerate dehydrogenase; Similar to PIR:A64427 percent identity: 55.960 in 305aa; owl:S75016 percent identity: 43.709 in 304aa; owl:CEC31C91 percent identity: 41.391 in 304aa. motif=ATP/GTP-binding site motif A (P-loop); D-isomer specific 2-hydroxyacid dehydrogenases signatures.
  
  
 0.639
PH1593
422aa long hypothetical glutamate dehydrogenase; Similar to owl:A47410 percent identity: 96.429 in 420aa; Swiss_Prot:P80319 percent identity: 95.952 in 420aa; owl:THCGLUDEHY percent identity: 87.799 in 419aa. motif=glu / Leu / Phe / Val dehydrogenases active site; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
  
 0.620
PH0857
394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
  
 0.610
PH1406
440aa long hypothetical threonine synthase; Similar to PIR:H64482 percent identity: 41.525 in 374aa; Swiss_Prot:Q10610 percent identity: 35.254 in 303aa; Swiss_Prot:P45837 percent identity: 34.915 in 303aa.
  
  
 0.610
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.