STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1317138aa long hypothetical glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (138 aa)    
Predicted Functional Partners:
PH1146
401aa long hypothetical aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
PH1994
502aa long hypothetical glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
 0.999
PH1995
449aa long hypothetical glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
 0.999
PH1654
427aa long hypothetical serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.986
PH1487
249aa long hypothetical lipoate protein ligase; Similar to owl:BSY1408318 percent identity: 38.835 in 216aa; owl:S73775 percent identity: 30.542 in 208aa.
 
 
 0.965
PH0359
443aa long hypothetical glutamine synthetase; Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
  
 
 0.850
PH1955
227aa long hypothetical phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL an [...]
  
 
  0.826
PH1593
422aa long hypothetical glutamate dehydrogenase; Similar to owl:A47410 percent identity: 96.429 in 420aa; Swiss_Prot:P80319 percent identity: 95.952 in 420aa; owl:THCGLUDEHY percent identity: 87.799 in 419aa. motif=glu / Leu / Phe / Val dehydrogenases active site; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.810
PH0876
472aa long hypothetical glutamate synthase small chain; Similar to owl:D86223 percent identity: 76.972 in 476aa; owl:ECAE0003335 percent identity: 39.052 in 457aa; Swiss_Prot:P09832 percent identity: 37.251 in 466aa.
    
 0.807
PH1873
476aa long hypothetical glutamate synthase small chain; Similar to owl:D86223 percent identity: 82.553 in 472aa; PIR:JC5184 percent identity: 39.002 in 460aa; Swiss_Prot:P09832 percent identity: 36.947 in 472aa.
    
 0.807
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.