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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1406440aa long hypothetical threonine synthase; Similar to PIR:H64482 percent identity: 41.525 in 374aa; Swiss_Prot:Q10610 percent identity: 35.254 in 303aa; Swiss_Prot:P45837 percent identity: 34.915 in 303aa. (440 aa)    
Predicted Functional Partners:
PH1087
271aa long hypothetical homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.979
PH1627
346aa long hypothetical threonine synthase; Similar to PIR:H64482 percent identity: 36.111 in 357aa.
  
  
 
0.915
PH0857
394aa long hypothetical threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
  
 
0.909
PH0655
348aa long hypothetical dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate. Is much less efficient when using NADP(+) instead of NAD(+). To a lesser extent, also catalyzes the oxidation of L-serine and DL-threo-3- phenylserine, but not that of L-allo-threonine, D-threonine and D-allo- threonine and many other L-amino acids.
   
 
 0.907
PH1075
319aa long hypothetical homoserine dehydrogenase; Similar to PIR:A64500 percent identity: 34.967 in 329aa.
 
 
 0.860
PH1408
226aa long hypothetical protein; Catalyzes the reversible phosphorylation of UMP to UDP.
  
  
 0.780
PH1404
651aa long hypothetical protein; Similar to PIR:C64454 percent identity: 59.841 in 641aa; PIR:C64320 percent identity: 40.548 in 395aa; PIR:G64305 percent identity: 38.047 in 314aa.
       0.778
PH1724
163aa long hypothetical 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
  
 0.686
PH0858
359aa long hypothetical protein; Similar to PIR:C64371 percent identity:43.558 in 169aa. motif=aspartokinase signature; Belongs to the aspartokinase family.
  
 
 0.667
PH1086
346aa long hypothetical aspartokinase; Similar to Swiss_Prot:P26512 percent identity:34.375 in 130aa; PIR:C64371 percent identity:35.948 in 157aa; OWL:TTHASKAB percent identity:32.308 in 131aa. motif=aspartokinase signature.
  
 
 0.667
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.