close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1498222aa long hypothetical endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (222 aa)    
Predicted Functional Partners:
PH1905
281aa long hypothetical protein; Similar to PIR:E64316 percent identity: 51.311 in 273aa; owl:SS100KBFR82 percent identity: 37.453 in 276aa.
  
 
 0.843
PH0661
211aa long hypothetical protein; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
     
 0.819
PH1500
148aa long hypothetical protein.
       0.819
PH1830
334aa long hypothetical glyceraldehyde-3-phosphate dehydrogenase; Similar to Swiss_Prot:P20286 percent identity: 90.719 in 334aa; Swiss_Prot:P10618 percent identity: 56.061 in 334aa; Swiss_Prot:P19315 percent identity: 57.751 in 335aa. motif=glyceraldehyde 3-phosphate dehydrogenase active site.
   
 
 0.779
PH0128
253aa long hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.
     
 0.769
PH1229
239aa long hypothetical protein; DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double- stranded DNA substrates.
      
 0.701
PH1415
343aa long hypothetical 5' nuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 
 0.669
PH0697
641aa long hypothetical protein; motif=ATP/GTP-binding site motif A (P-loop).
     
 0.607
PH0784
283aa long hypothetical DNA-3-methyladenine glycosidase; Similar to Swiss_Prot:P37878 percent identity:31.282 in 205aa.
   
 
 0.593
PH1501
438aa long hypothetical aminotransferase; Similar to owl:D5045389 percent identity: 38.287 in 401aa; Swiss_Prot:P30268 percent identity: 36.409 in 409aa; Swiss_Prot:P22256 percent identity: 36.750 in 409aa. motif=aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
       0.553
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.