close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1537312aa long hypothetical nucleolar protein; Similar to owl:D908275 percent identity: 44.298 in 236aa; owl:A48998 percent identity: 38.376 in 277aa; Swiss_Prot:P40991 percent identity: 39.483 in 278aa; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (312 aa)    
Predicted Functional Partners:
PH1536
142aa long hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
     
 0.941
PH0281
174aa long hypothetical protein; Belongs to the UPF0113 family.
  
 
 0.740
PH1320
357aa long hypothetical protein; Similar to PIR:G64475 percent identity: 53.395 in 332aa; owl:S61973 percent identity: 31.615 in 291aa. motif=ATP/GTP-binding site motif A (P-loop).
   
 
 0.730
PH0645
355aa long hypothetical GTP-binding protein; Similar to PIR:G64482 percent identity: 43.825 in 251aa; owl:HUMAUANTIG percent identity: 36.145 in 261aa; owl:MMU69600 percent identity: 36.000 in 262aa. motif=ATP/GTP-binding site motif A (P-loop).
  
 
 0.724
PH0338
329aa long hypothetical protein; Similar to PIR:F64388 percent identity:45.283 in 168aa; Swiss_Prot:P05409 percent identity:39.423 in 111aa. motif=N-6 Adenine-specific DNA methylases signature.
   
 
 0.687
PH0053
404aa long hypothetical protein; Similar to PIR:F64386 percent identity: 52.669 in 283aa; owl:CEK07C53 percent identity: 39.249 in 306aa; owl:HSNOP56 percent identity: 41.102 in 239aa.
   
 
 0.678
PH1103
127aa long hypothetical 30S ribosomal protein S8; Similar to Swiss_Prot:P54055 percent identity: 62.992 in 129aa; Swiss_Prot:P49402 percent identity: 49.167 in 122aa.
   
 
 0.658
PH1900
334aa long hypothetical protein; Probably involved in the biogenesis of the ribosome.
  
 
 0.641
PH1999
342aa long hypothetical acidic ribosomal protein P0 (L10E); Forms the large subunit's ribosomal stalk, playing a central role in the interaction of the ribosome with elongation factors; the stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes, although the first site is the most stimulatory; Belongs to the universal ribosomal protein uL10 family.
  
 
 0.632
PH0635
254aa long hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
     
 0.625
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.