Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PH1537312aa long hypothetical nucleolar protein; Similar to owl:D908275 percent identity: 44.298 in 236aa; owl:A48998 percent identity: 38.376 in 277aa; Swiss_Prot:P40991 percent identity: 39.483 in 278aa; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (312 aa)    
Predicted Functional Partners:
PH1536
142aa long hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
     
 0.956
PH0281
174aa long hypothetical protein; Belongs to the UPF0113 family.
  
 
 0.722
PH0951
283aa long hypothetical 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
  
    0.678
PH0098
158aa long hypothetical protein.
       0.671
PH1240
129aa long hypothetical protein.
       0.671
PH1596
215aa long hypothetical protein; Similar to PIR:E64452 percent identity: 39.063 in 203aa.
       0.671
PH1602
871aa long hypothetical protein; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.
       0.671
PH0053
404aa long hypothetical protein; Similar to PIR:F64386 percent identity: 52.669 in 283aa; owl:CEK07C53 percent identity: 39.249 in 306aa; owl:HSNOP56 percent identity: 41.102 in 239aa.
   
 
 0.669
PH0645
355aa long hypothetical GTP-binding protein; Similar to PIR:G64482 percent identity: 43.825 in 251aa; owl:HUMAUANTIG percent identity: 36.145 in 261aa; owl:MMU69600 percent identity: 36.000 in 262aa. motif=ATP/GTP-binding site motif A (P-loop).
  
 
 0.665
PH1320
357aa long hypothetical protein; Similar to PIR:G64475 percent identity: 53.395 in 332aa; owl:S61973 percent identity: 31.615 in 291aa. motif=ATP/GTP-binding site motif A (P-loop).
   
 
 0.663
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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