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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH1955227aa long hypothetical phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL an [...] (227 aa)    
Predicted Functional Partners:
PH0316
334aa long hypothetical phosphoribosylformylglycinamide cyclo-ligase; Similar to PIR:D64325 percent identity: 55.738 in 317aa; Swiss_Prot:P12043 percent identity: 42.679 in 335aa; Swiss_Prot:P43848 percent identity: 43.279 in 317aa.
 
 0.999
PH1953
705aa long hypothetical phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...]
 0.999
PH0240
449aa long hypothetical amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 
 0.998
PH0323
438aa long hypothetical phosphoribosylamide--glycine ligase; Similar to PIR:A64417 percent identity: 55.478 in 442aa; owl:HUMRPS4 percent identity: 33.738 in 424aa; Swiss_Prot:P12039 percent identity: 33.819 in 352aa. motif=prokaryotic membrane lipoprotein lipid attachment site.
  
 0.998
PH0318
433aa long hypothetical phosphoribosylglycinamide formyl transferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
  
 
 0.997
PH0239
238aa long hypothetical phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to PIR:G64498 percent identity: 52.814 in 232aa; Swiss_Prot:P12046 percent identity: 49.785 in 235aa; Swiss_Prot:Q07296 percent identity: 48.214 in 227aa. motif=SAICAR synthetase signatures.
  
  
 0.978
PH0320
177aa long hypothetical phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
  
 0.978
PH0852
450aa long hypothetical adenylosuccinate lyase; Similar to PIR:A64416 percent identity: 58.864 in 443aa; Swiss_Prot:P12047 percent identity: 42.373 in 419aa; owl:S76222 percent identity: 41.769 in 414aa. motif=fumarate lyases signature.
  
  
 0.965
PH0243
601aa long hypothetical glutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
    
 0.934
PH0359
443aa long hypothetical glutamine synthetase; Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
    
 0.921
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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