Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
sbcDSbcD; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (403 aa)    
Predicted Functional Partners:
sbcC
SbcC; Exonuclease SbcC; Similar to Pantoea sp. At-9b, exonuclease SbcC (NCBI: ZP_05727438.1); COG: DNA replication, recombination and repair; Subcellular localization as predicted by Psort 2.0: Cytoplasmic.
 
 0.999
polA
PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.925
recQ
RecQ; ATP-dependent DNA helicase RecQ; Similar to Pantoea sp. At-9b, ATP-dependent DNA helicase RecQ (NCBI: ZP_05730688.1); COG: DNA replication, recombination and repair; Subcellular localization as predicted by Psort 2.0: Cytoplasmic.
  
 0.849
tolA
TolA; Hypothetical Protein TolA; Similar to Pantoea sp. At-9b, hypothetical protein Pat9bDRAFT_0749 (NCBI: ZP_05727434.1); COG: Cell wall/membrane/envelope biogenesis; Subcellular localization as predicted by Psort 2.0: Unknown.
     
 0.775
recA
RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.771
xni
Xni; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
   
 0.718
rapA
RapA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
 
 
 0.715
recD
RecD; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any li [...]
   
 
 0.677
mutL
MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 
 0.629
phoR
PhoR; Phosphate regulon sensor protein PhoR; Similar to Pantoea sp. At-9b, PAS/PAC sensor signal transduction histidine kinase (NCBI: ZP_05727441.1); COG: Signal transduction mechanisms; Subcellular localization as predicted by Psort 2.0: Inner Membrane.
 
     0.627
Your Current Organism:
Pantoea ananatis
NCBI taxonomy Id: 706191
Other names: P. ananatis LMG 20103, Pantoea ananatis LMG 20103, Pantoea ananatis str. LMG 20103, Pantoea ananatis strain LMG 20103
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