STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aptApt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (204 aa)    
Predicted Functional Partners:
guaA-2
GuaA; Catalyzes the synthesis of GMP from XMP.
  
 0.988
purH
PurH; Bifunctional purine biosynthesis protein PurH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase]; Similar to Pantoea sp. At-9b, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI: ZP_05732296.1); COG: Nucleotide transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown.
 
 0.960
gmk
Gmk; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.959
purB
PurB; Adenylosuccinate lyase; Similar to Pantoea sp. At-9b, adenylosuccinate lyase (NCBI: ZP_05728421.1); COG: Nucleotide transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown.
  
 0.944
gpt
Gpt; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
  
 
 0.936
adk
Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 
 0.929
guaC
GuaC; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
  
 
 0.926
guaA
GuaA; GMP synthase [glutamine- hydrolyzing]; Similar to Pantoea sp. At-9b, glutamine amidotransferase class-I (NCBI: ZP_05728465.1); COG: Nucleotide transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown.
  
 
 0.926
hpt
Hpt; Hypoxanthine phosphoribosyltransferase; Similar to Pantoea sp. At-9b, hypoxanthine phosphoribosyltransferase (NCBI: ZP_05729839.1); COG: Nucleotide transport and metabolism; Subcellular localization as predicted by Psort 2.0: Cytoplasmic; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
   
 0.925
gsk
Gsk; Inosine-guanosine kinase; Similar to Pantoea sp. At-9b, Inosine kinase (NCBI: ZP_05727529.1); COG: Carbohydrate transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown.
   
 0.919
Your Current Organism:
Pantoea ananatis
NCBI taxonomy Id: 706191
Other names: P. ananatis LMG 20103, Pantoea ananatis LMG 20103, Pantoea ananatis str. LMG 20103, Pantoea ananatis strain LMG 20103
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.