Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
hisGHisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa)    
Predicted Functional Partners:
hisI
HisI; Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMP cyclohydrolase]; Similar to Pantoea sp. At-9b, phosphoribosyl-ATP diphosphatase (NCBI: ZP_05729030.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Cytoplasmic; In the N-terminal section; belongs to the PRA-CH family.
 
 
 0.999
hisD
HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.998
hisC
HisC; Histidinol-phosphate aminotransferase; Similar to Pantoea sp. At-9b, histidinol-phosphate aminotransferase (NCBI: ZP_05729025.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.998
hisB
HisB; Histidine biosynthesis bifunctional protein HisB [Includes: Histidinol-phosphatase]; Similar to Pantoea sp. At-9b, histidinol-phosphatase (NCBI: ZP_05729026.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Cytoplasmic.
 
  
 0.997
hisA
HisA; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Similar to Pantoea sp. At-9b, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (NCBI: ZP_05729028.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Cytoplasmic.
 
  
 0.990
hisH
HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.988
hisF
HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.988
prs
Prs; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.878
feoB
FeoB; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
  
  
 0.875
trpC
TrpC; Tryptophan biosynthesis protein trpCF [Includes: Indole-3-glycerol phosphate synthase; Similar to Pantoea sp. At-9b, Indole-3-glycerol-phosphate synthase, Phosphoribosylanthranilate isomerase (NCBI: ZP_05729317.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown.
 
  
 0.853
Your Current Organism:
Pantoea ananatis
NCBI taxonomy Id: 706191
Other names: P. ananatis LMG 20103, Pantoea ananatis LMG 20103, Pantoea ananatis str. LMG 20103, Pantoea ananatis strain LMG 20103
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