STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisGHisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa)    
Predicted Functional Partners:
hisI
HisI; Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMP cyclohydrolase]; Similar to Pantoea sp. At-9b, phosphoribosyl-ATP diphosphatase (NCBI: ZP_05729030.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Cytoplasmic; In the N-terminal section; belongs to the PRA-CH family.
 
 
 0.999
hisB
HisB; Histidine biosynthesis bifunctional protein HisB [Includes: Histidinol-phosphatase]; Similar to Pantoea sp. At-9b, histidinol-phosphatase (NCBI: ZP_05729026.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Cytoplasmic.
 
  
 0.997
hisD
HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.995
hisC
HisC; Histidinol-phosphate aminotransferase; Similar to Pantoea sp. At-9b, histidinol-phosphate aminotransferase (NCBI: ZP_05729025.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.995
hisH
HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.979
hisA
HisA; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Similar to Pantoea sp. At-9b, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (NCBI: ZP_05729028.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Cytoplasmic.
 
  
 0.979
hisF
HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.979
prs
Prs; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.875
thrA
ThrA; Bifunctional aspartokinase/homoserine dehydrogenase I; Similar to Pantoea sp. At-9b, aspartate kinase (NCBI: ZP_05729729.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown; In the C-terminal section; belongs to the homoserine dehydrogenase family.
 
  
 0.832
metL
MetL; Bifunctional aspartokinase/homoserine dehydrogenase II; Similar to Pantoea sp. At-9b, aspartate kinase (NCBI: ZP_05730334.1); COG: Amino acid transport and metabolism; Subcellular localization as predicted by Psort 2.0: Inner Membrane; In the C-terminal section; belongs to the homoserine dehydrogenase family.
 
  
 0.814
Your Current Organism:
Pantoea ananatis
NCBI taxonomy Id: 706191
Other names: P. ananatis LMG 20103, Pantoea ananatis LMG 20103, Pantoea ananatis str. LMG 20103, Pantoea ananatis strain LMG 20103
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