Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
surESurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (250 aa)    
Predicted Functional Partners:
pcm
Pcm; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
  
 0.972
guaA-2
GuaA; Catalyzes the synthesis of GMP from XMP.
    
 0.969
yjjG
YjjG; 5'-nucleotidase YjjG; Similar to Pantoea sp. At-9b, HAD-superfamily hydrolase, subfamily IA, variant 1 (NCBI: ZP_05730074.1); COG: Nucleotide transport and metabolism; Subcellular localization as predicted by Psort 2.0: Unknown.
    
 0.936
ushA
UshA; Protein UshA precursor [Includes: UDP-sugar hydrolase]; Similar to Pantoea sp. At-9b, 5'-Nucleotidase domain protein (NCBI: ZP_05727532.1); COG: Nucleotide transport and metabolism; Subcellular localization as predicted by Psort 2.0: Periplasmic; Belongs to the 5'-nucleotidase family.
     
 0.935
yfbR
YfbR; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates.
     
 0.935
pyrH
PyrH; Catalyzes the reversible phosphorylation of UMP to UDP.
  
  
 0.931
dut
Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
 
  
 0.931
hpt
Hpt; Hypoxanthine phosphoribosyltransferase; Similar to Pantoea sp. At-9b, hypoxanthine phosphoribosyltransferase (NCBI: ZP_05729839.1); COG: Nucleotide transport and metabolism; Subcellular localization as predicted by Psort 2.0: Cytoplasmic; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
     
 0.927
cmk
Cmk; Cytidylate kinase; Similar to Pantoea sp. At-9b, cytidylate kinase (NCBI: ZP_05728885.1); COG: Nucleotide transport and metabolism; Subcellular localization as predicted by Psort 2.0: Cytoplasmic.
    
 0.925
apt
Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
 0.924
Your Current Organism:
Pantoea ananatis
NCBI taxonomy Id: 706191
Other names: P. ananatis LMG 20103, Pantoea ananatis LMG 20103, Pantoea ananatis str. LMG 20103, Pantoea ananatis strain LMG 20103
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