STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polCDNA polymerase III, alpha subunit, Gram-positive type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1449 aa)    
Predicted Functional Partners:
EFW24073.1
KEGG: cby:CLM_0308 1.5e-31 exonuclease, DNA polymerase III, epsilon subunit family; K02342 DNA polymerase III subunit epsilon; Psort location: Cytoplasmic, score: 9.97.
  
 
0.954
dnaX
DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 0.939
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.936
EFW24495.1
KEGG: gwc:GWCH70_2690 5.2e-194 DNA polymerase III, alpha subunit K02337; Psort location: Cytoplasmic, score: 9.97.
    
0.935
holB
KEGG: bbe:BBR47_00780 2.8e-37 holB; DNA polymerase III delta' subunit K02341; Psort location: Cytoplasmic, score: 7.50.
  
 0.921
holA
KEGG: bcg:BCG9842_B0794 8.9e-25 holA; DNA polymerase III subunit delta K02340; Psort location: Cytoplasmic, score: 7.50.
    
 0.920
EFW24132.1
UvrD/REP helicase; KEGG: sac:SACOL1966 3.4e-142 pcrA; ATP-dependent DNA helicase PcrA K03657; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.738
tmcAL
Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
 
    0.687
ligA
NAD-dependent DNA ligase OB-fold domain protein; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
  
 
 0.664
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.661
Your Current Organism:
Solobacterium moorei
NCBI taxonomy Id: 706433
Other names: S. moorei F0204, Solobacterium moorei F0204, Solobacterium moorei str. F0204, Solobacterium moorei strain F0204
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