AFM23895.1 protein (Desulfomonile tiedjei) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

AFM23895.1

PFAM: Tetratricopeptide repeat. (329 aa)

Predicted Functional Partners:

AFM24153.1

0.812

AFM25150.1

0.798

AFM24787.1

0.793

AFM25470.1

0.791

AFM23951.1

0.778

AFM26509.1

0.778

AFM27692.1

0.778

AFM24692.1

0.775

AFM26344.1

0.774

AFM26665.1

0.774

Your Current Organism:

Desulfomonile tiedjei

NCBI taxonomy Id: 706587
Other names: D. tiedjei DSM 6799, Desulfomonile tiedjei DCB-1, Desulfomonile tiedjei DSM 6799, Desulfomonile tiedjei str. DSM 6799, Desulfomonile tiedjei strain DSM 6799

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFM23895.1	AFM23951.1	Desti_1182	Desti_1238	PFAM: Tetratricopeptide repeat.	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	0.778
AFM23895.1	AFM24153.1	Desti_1182	Desti_1441	PFAM: Tetratricopeptide repeat.	TPR repeat-containing protein; PFAM: Tetratricopeptide repeat; SEC-C motif.	0.812
AFM23895.1	AFM24692.1	Desti_1182	Desti_1988	PFAM: Tetratricopeptide repeat.	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	0.775
AFM23895.1	AFM24787.1	Desti_1182	Desti_2088	PFAM: Tetratricopeptide repeat.	PFAM: Tetratricopeptide repeat.	0.793
AFM23895.1	AFM25150.1	Desti_1182	Desti_2469	PFAM: Tetratricopeptide repeat.	PFAM: Tetratricopeptide repeat.	0.798
AFM23895.1	AFM25470.1	Desti_1182	Desti_2800	PFAM: Tetratricopeptide repeat.	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	0.791
AFM23895.1	AFM26344.1	Desti_1182	Desti_3699	PFAM: Tetratricopeptide repeat.	PFAM: Tetratricopeptide repeat.	0.774
AFM23895.1	AFM26509.1	Desti_1182	Desti_3867	PFAM: Tetratricopeptide repeat.	PFAM: Tetratricopeptide repeat.	0.778
AFM23895.1	AFM26665.1	Desti_1182	Desti_4025	PFAM: Tetratricopeptide repeat.	Flp pilus assembly protein TadD; PFAM: Tetratricopeptide repeat.	0.774
AFM23895.1	AFM27692.1	Desti_1182	Desti_5082	PFAM: Tetratricopeptide repeat.	PFAM: Tetratricopeptide repeat.	0.778
AFM23951.1	AFM23895.1	Desti_1238	Desti_1182	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	PFAM: Tetratricopeptide repeat.	0.778
AFM23951.1	AFM24153.1	Desti_1238	Desti_1441	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	TPR repeat-containing protein; PFAM: Tetratricopeptide repeat; SEC-C motif.	0.818
AFM23951.1	AFM24787.1	Desti_1238	Desti_2088	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	PFAM: Tetratricopeptide repeat.	0.811
AFM23951.1	AFM25150.1	Desti_1238	Desti_2469	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	PFAM: Tetratricopeptide repeat.	0.748
AFM23951.1	AFM26344.1	Desti_1238	Desti_3699	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	PFAM: Tetratricopeptide repeat.	0.455
AFM23951.1	AFM26509.1	Desti_1238	Desti_3867	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	PFAM: Tetratricopeptide repeat.	0.761
AFM23951.1	AFM27692.1	Desti_1238	Desti_5082	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	PFAM: Tetratricopeptide repeat.	0.461
AFM24153.1	AFM23895.1	Desti_1441	Desti_1182	TPR repeat-containing protein; PFAM: Tetratricopeptide repeat; SEC-C motif.	PFAM: Tetratricopeptide repeat.	0.812
AFM24153.1	AFM23951.1	Desti_1441	Desti_1238	TPR repeat-containing protein; PFAM: Tetratricopeptide repeat; SEC-C motif.	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	0.818
AFM24153.1	AFM24692.1	Desti_1441	Desti_1988	TPR repeat-containing protein; PFAM: Tetratricopeptide repeat; SEC-C motif.	Tfp pilus assembly protein PilF; PFAM: Tetratricopeptide repeat.	0.785

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Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.869

expected number of edges:

13

PPI enrichment p-value:

1.41e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006506

GPI anchor biosynthetic process

4 of 30

2.59

3.1

1.48e-06

GO:0009398

FMN biosynthetic process

2 of 2

3.47

2.13

0.00015

GO:0090407

Organophosphate biosynthetic process

6 of 572

1.49

1.83

8.75e-06

GO:1901137

Carbohydrate derivative biosynthetic process

6 of 638

1.44

1.74

1.06e-05

GO:0019637

Organophosphate metabolic process

7 of 939

1.34

1.61

7.64e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008531

Riboflavin kinase activity

2 of 2

3.47

1.59

0.0014

GO:0003919

FMN adenylyltransferase activity

2 of 5

3.07

1.45

0.0024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030176

Integral component of endoplasmic reticulum membrane

2 of 70

1.92

0.72

0.0441

GO:0005789

Endoplasmic reticulum membrane

4 of 653

1.25

0.61

0.0419

GO:0031984

Organelle subcompartment

5 of 1567

0.97

0.52

0.0419

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12625

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

4 of 15

2.89

3.7

1.51e-07

CL:12628

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

3 of 10

2.94

2.71

1.12e-05

CL:9572

Purine nucleotide salvage, and Adenylate kinase activity

3 of 31

2.45

1.99

0.00019

CL:9944

Mixed, incl. Calcineurin-like phosphoesterase, and Nicotinamide nucleotide metabolic process

3 of 46

2.28

1.84

0.00032

CL:9958

Riboflavin kinase domain superfamily, and Nudix N-terminal

2 of 5

3.07

1.67

0.00098

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

4 of 29

2.6

3.87

4.55e-08

map00740

Riboflavin metabolism

3 of 79

2.04

1.86

0.00020

map01100

Metabolic pathways

9 of 6166

0.63

0.51

0.00067

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163125

Post-translational modification: synthesis of GPI-anchored proteins

4 of 30

2.59

3.46

2.92e-07

MAP-196843

Vitamin B2 (riboflavin) metabolism

2 of 6

2.99

1.6

0.0013

MAP-162710

Synthesis of glycosylphosphatidylinositol (GPI)

2 of 19

2.49

1.2

0.0063

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042765

GPI-anchor transamidase complex

2 of 6

2.99

1.33

0.0040

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023198

Phosphoglycolate phosphatase-like, domain 2

4 of 13

2.95

3.79

1.10e-07

IPR023465

Riboflavin kinase domain superfamily

3 of 3

3.47

3.34

9.32e-07

IPR015865

Riboflavin kinase domain, bacterial/eukaryotic

3 of 3

3.47

3.34

9.32e-07

IPR006439

HAD hydrolase, subfamily IA

4 of 26

2.65

3.31

6.34e-07

IPR041492

Haloacid dehalogenase-like hydrolase

4 of 28

2.62

3.3

6.34e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00904

Riboflavin kinase

2 of 2

3.47

1.94

0.00033

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