STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (221 aa)    
Predicted Functional Partners:
AFM24251.1
PFAM: Phosphomethylpyrimidine kinase; Archaeal phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase.
 
 0.999
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
 
 0.999
thiL
Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
 
  
 0.948
AFM27761.1
Iron-only hydrogenase maturation protein HydG; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: [FeFe] hydrogenase H-cluster radical SAM maturase HydG; thiazole biosynthesis protein ThiH.
 
  
 0.940
AFM23823.1
PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS.
  
  
 0.923
AFM23482.1
PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC.
  
 0.911
AFM27034.1
Hydroxymethylpyrimidine synthase; PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC.
  
 0.905
AFM28144.1
Hydroxymethylpyrimidine synthase; PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC.
  
 0.905
AFM23675.1
PFAM: Alkaline phosphatase; Belongs to the alkaline phosphatase family.
    
  0.904
AFM27289.1
Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis; PFAM: MoeZ/MoeB domain; ThiF family.
 
  
 0.871
Your Current Organism:
Desulfomonile tiedjei
NCBI taxonomy Id: 706587
Other names: D. tiedjei DSM 6799, Desulfomonile tiedjei DCB-1, Desulfomonile tiedjei DSM 6799, Desulfomonile tiedjei str. DSM 6799, Desulfomonile tiedjei strain DSM 6799
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