STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFM26748.1(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (775 aa)    
Predicted Functional Partners:
AFM26744.1
Hydrogenase maturation protein, carbamoyl dehydratase HypE; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: hydrogenase expression/formation protein HypE.
 
 
 0.991
AFM26745.1
PFAM: Hydrogenase formation hypA family; TIGRFAM: hydrogenase expression/formation protein HypD; Belongs to the HypD family.
 
  
 0.919
AFM26746.1
PFAM: HupF/HypC family; TIGRFAM: hydrogenase assembly chaperone HypC/HupF.
 
 
 0.915
hypA
Hydrogenase-3 nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.863
AFM28218.1
Ni2+-binding GTPase, urease/hydrogenase maturation protein; PFAM: CobW/HypB/UreG, nucleotide-binding domain; TIGRFAM: hydrogenase accessory protein HypB.
 
   
 0.863
AFM26389.1
Ni,Fe-hydrogenase I large subunit; PFAM: Nickel-dependent hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 
 0.862
AFM26390.1
Hydrogenase (NiFe) small subunit HydA; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; hydrogenase (NiFe) small subunit (hydA).
 
 
 
 0.837
AFM25815.1
PFAM: Hydrogenase maturation protease; TIGRFAM: hydrogenase expression/formation protein; hydrogenase maturation protease.
 
   
 0.823
AFM23079.1
Coenzyme F420-reducing hydrogenase, alpha subunit; PFAM: Nickel-dependent hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
   
 0.809
AFM23080.1
Coenzyme F420-reducing hydrogenase, gamma subunit; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit.
 
  
 0.714
Your Current Organism:
Desulfomonile tiedjei
NCBI taxonomy Id: 706587
Other names: D. tiedjei DSM 6799, Desulfomonile tiedjei DCB-1, Desulfomonile tiedjei DSM 6799, Desulfomonile tiedjei str. DSM 6799, Desulfomonile tiedjei strain DSM 6799
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