SSLN_LOCUS371 protein (Schistocephalus solidus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

SSLN_LOCUS371

TFIID_NTD2 domain-containing protein. (361 aa)

Predicted Functional Partners:

SSLN_LOCUS5696

0.987

A0A183TJX5

0.986

SSLN_LOCUS7726

0.985

SSLN_LOCUS58

0.985

SSLN_LOCUS4166

0.985

SSLN_LOCUS8512

0.985

A0A183T120

0.985

A0A183T4F6

0.985

A0A183T8C3

0.985

A0A183TD81

0.985

Your Current Organism:

Schistocephalus solidus

NCBI taxonomy Id: 70667
Other names: S. solidus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A183T120	A0A183T4F6	A0A183T120	A0A183T4F6	Uncharacterized protein.	Transcription initiation factor TFIID subunit 11.	0.998
A0A183T120	A0A183T8C3	A0A183T120	A0A183T8C3	Uncharacterized protein.	TAFII55_N domain-containing protein.	0.998
A0A183T120	A0A183TD81	A0A183T120	A0A183TD81	Uncharacterized protein.	Transcription initiation factor TFIID subunit 10.	0.998
A0A183T120	A0A183TJX5	A0A183T120	A0A183TJX5	Uncharacterized protein.	Transcription initiation factor TFIID subunit 6.	0.998
A0A183T120	SSLN_LOCUS371	A0A183T120	A0A183S824	Uncharacterized protein.	TFIID_NTD2 domain-containing protein.	0.985
A0A183T120	SSLN_LOCUS4166	A0A183T120	A0A183SIW8	Uncharacterized protein.	Uncharacterized protein.	0.998
A0A183T120	SSLN_LOCUS5696	A0A183T120	A0A183SN98	Uncharacterized protein.	TFIID_20kDa domain-containing protein.	0.998
A0A183T120	SSLN_LOCUS58	A0A183T120	A0A183S760	Uncharacterized protein.	TAF8_C domain-containing protein.	0.998
A0A183T120	SSLN_LOCUS7726	A0A183T120	A0A0X3PQT5	Uncharacterized protein.	Uncharacterized protein.	0.998
A0A183T120	SSLN_LOCUS8512	A0A183T120	A0A183SWB4	Uncharacterized protein.	TAFH domain-containing protein.	0.998
A0A183T4F6	A0A183T120	A0A183T4F6	A0A183T120	Transcription initiation factor TFIID subunit 11.	Uncharacterized protein.	0.998
A0A183T4F6	A0A183T8C3	A0A183T4F6	A0A183T8C3	Transcription initiation factor TFIID subunit 11.	TAFII55_N domain-containing protein.	0.997
A0A183T4F6	A0A183TD81	A0A183T4F6	A0A183TD81	Transcription initiation factor TFIID subunit 11.	Transcription initiation factor TFIID subunit 10.	0.998
A0A183T4F6	A0A183TJX5	A0A183T4F6	A0A183TJX5	Transcription initiation factor TFIID subunit 11.	Transcription initiation factor TFIID subunit 6.	0.999
A0A183T4F6	SSLN_LOCUS371	A0A183T4F6	A0A183S824	Transcription initiation factor TFIID subunit 11.	TFIID_NTD2 domain-containing protein.	0.985
A0A183T4F6	SSLN_LOCUS4166	A0A183T4F6	A0A183SIW8	Transcription initiation factor TFIID subunit 11.	Uncharacterized protein.	0.998
A0A183T4F6	SSLN_LOCUS5696	A0A183T4F6	A0A183SN98	Transcription initiation factor TFIID subunit 11.	TFIID_20kDa domain-containing protein.	0.999
A0A183T4F6	SSLN_LOCUS58	A0A183T4F6	A0A183S760	Transcription initiation factor TFIID subunit 11.	TAF8_C domain-containing protein.	0.999
A0A183T4F6	SSLN_LOCUS7726	A0A183T4F6	A0A0X3PQT5	Transcription initiation factor TFIID subunit 11.	Uncharacterized protein.	0.998
A0A183T4F6	SSLN_LOCUS8512	A0A183T4F6	A0A183SWB4	Transcription initiation factor TFIID subunit 11.	TAFH domain-containing protein.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.871

expected number of edges:

12

PPI enrichment p-value:

6.15e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051754

Meiotic sister chromatid cohesion, centromeric

4 of 6

3.29

4.5

6.75e-09

GO:0007094

Mitotic spindle assembly checkpoint signaling

4 of 12

2.99

4.19

1.95e-08

GO:0019220

Regulation of phosphate metabolic process

5 of 212

1.84

2.68

6.04e-07

GO:0006470

Protein dephosphorylation

4 of 192

1.78

2.02

3.25e-05

GO:0007165

Signal transduction

5 of 1728

0.93

0.64

0.0088

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019888

Protein phosphatase regulator activity

5 of 85

2.23

3.37

1.49e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000159

Protein phosphatase type 2A complex

5 of 34

2.63

4.76

7.62e-10

GO:0000776

Kinetochore

4 of 26

2.65

3.96

3.33e-08

GO:0010369

Chromocenter

2 of 4

3.16

2.15

0.00013

GO:0005828

Kinetochore microtubule

2 of 4

3.16

2.15

0.00013

GO:0005829

Cytosol

5 of 2313

0.8

0.48

0.0269

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6644

Cyclin A/B1/B2 associated events during G2/M transition, and Protein phosphatase 2A, regulatory B subunit, B56

7 of 38

2.73

7.18

1.12e-14

CL:6645

Cyclin A/B1/B2 associated events during G2/M transition, and Protein phosphatase 2A, regulatory B subunit, B56

4 of 30

2.59

3.56

1.81e-07

CL:6704

CTLA4 inhibitory signaling, and Protein phosphatase 2A regulatory subunit PR55

3 of 8

3.04

3.09

2.35e-06

CL:19076

Inactivation of APC/C via direct inhibition of the APC/C complex, and Mad3/Bub1 homology region 1

3 of 28

2.5

2.31

4.68e-05

CL:19057

Anaphase-promoting complex-dependent catabolic process, and Cell cycle phase transition

4 of 108

2.03

2.3

1.99e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03015

mRNA surveillance pathway

6 of 296

1.77

2.92

4.38e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389513

CTLA4 inhibitory signaling

6 of 32

2.74

6.55

2.36e-13

MAP-69273

Cyclin A/B1/B2 associated events during G2/M transition

6 of 33

2.72

6.54

2.36e-13

MAP-5673000

RAF activation

6 of 34

2.71

6.52

2.36e-13

MAP-388841

Costimulation by the CD28 family

6 of 36

2.69

6.49

2.36e-13

MAP-450282

MAPK targets/ Nuclear events mediated by MAP kinases

5 of 20

2.86

5.96

6.09e-12

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990706

MAD1 complex

4 of 4

3.47

5.06

7.01e-10

GOCC:0000779

Condensed chromosome, centromeric region

4 of 22

2.72

3.81

7.46e-08

GOCC:0000159

Protein phosphatase type 2A complex

4 of 23

2.71

3.8

7.46e-08

GOCC:0000776

Kinetochore

4 of 26

2.65

3.78

7.46e-08

GOCC:1990728

Mitotic spindle assembly checkpoint MAD1-MAD2 complex

2 of 2

3.47

2.26

8.61e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13646

HEAT repeats

3 of 7

3.1

2.82

7.56e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013212

Mad3/Bub1 homology region 1

4 of 4

3.47

4.69

3.25e-09

IPR021133

HEAT, type 2

4 of 23

2.71

3.43

4.06e-07

IPR015661

Mitotic spindle checkpoint protein Bub1/Mad3

3 of 3

3.47

3.27

1.24e-06

IPR011989

Armadillo-like helical

5 of 336

1.64

1.73

8.96e-05

IPR016024

Armadillo-type fold

5 of 411

1.55

0.00019

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00777

Mad3/BUB1 hoMad3/BUB1 homology region 1

2 of 2

3.47

1.94

0.00033

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