A0A183T271 protein (Schistocephalus solidus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

A0A183T271

Uncharacterized protein. (2193 aa)

Predicted Functional Partners:

SSLN_LOCUS5842

0.895

SSLN_LOCUS3695

0.751

SSLN_LOCUS3696

0.751

A0A183TDG0

0.751

SSLN_LOCUS2200

0.751

SSLN_LOCUS3620

0.720

SSLN_LOCUS210

0.697

SSLN_LOCUS8462

0.691

A0A183TE42

0.688

SSLN_LOCUS3804

0.677

Your Current Organism:

Schistocephalus solidus

NCBI taxonomy Id: 70667
Other names: S. solidus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A183T271	A0A183TDG0	A0A183T271	A0A183TDG0	Uncharacterized protein.	Uncharacterized protein.	0.751
A0A183T271	A0A183TE42	A0A183T271	A0A183TE42	Uncharacterized protein.	Macro domain-containing protein.	0.688
A0A183T271	SSLN_LOCUS210	A0A183T271	A0A3P7DB34	Uncharacterized protein.	SF3b1 domain-containing protein.	0.697
A0A183T271	SSLN_LOCUS2200	A0A183T271	A0A3P7C3C3	Uncharacterized protein.	Uncharacterized protein.	0.751
A0A183T271	SSLN_LOCUS3620	A0A183T271	A0A183SHC2	Uncharacterized protein.	Uncharacterized protein.	0.720
A0A183T271	SSLN_LOCUS3695	A0A183T271	A0A183SHJ7	Uncharacterized protein.	Uncharacterized protein.	0.751
A0A183T271	SSLN_LOCUS3696	A0A183T271	A0A183SHJ8	Uncharacterized protein.	Uncharacterized protein.	0.751
A0A183T271	SSLN_LOCUS3804	A0A183T271	A0A183SHV6	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.677
A0A183T271	SSLN_LOCUS5842	A0A183T271	A0A183SNP4	Uncharacterized protein.	Uncharacterized protein.	0.895
A0A183T271	SSLN_LOCUS8462	A0A183T271	A0A183SW64	Uncharacterized protein.	CBFD_NFYB_HMF domain-containing protein.	0.691
A0A183TDG0	A0A183T271	A0A183TDG0	A0A183T271	Uncharacterized protein.	Uncharacterized protein.	0.751
A0A183TDG0	A0A183TE42	A0A183TDG0	A0A183TE42	Uncharacterized protein.	Macro domain-containing protein.	0.798
A0A183TDG0	SSLN_LOCUS210	A0A183TDG0	A0A3P7DB34	Uncharacterized protein.	SF3b1 domain-containing protein.	0.691
A0A183TDG0	SSLN_LOCUS3620	A0A183TDG0	A0A183SHC2	Uncharacterized protein.	Uncharacterized protein.	0.687
A0A183TDG0	SSLN_LOCUS3804	A0A183TDG0	A0A183SHV6	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.775
A0A183TDG0	SSLN_LOCUS8462	A0A183TDG0	A0A183SW64	Uncharacterized protein.	CBFD_NFYB_HMF domain-containing protein.	0.820
A0A183TE42	A0A183T271	A0A183TE42	A0A183T271	Macro domain-containing protein.	Uncharacterized protein.	0.688
A0A183TE42	A0A183TDG0	A0A183TE42	A0A183TDG0	Macro domain-containing protein.	Uncharacterized protein.	0.798
A0A183TE42	SSLN_LOCUS210	A0A183TE42	A0A3P7DB34	Macro domain-containing protein.	SF3b1 domain-containing protein.	0.537
A0A183TE42	SSLN_LOCUS2200	A0A183TE42	A0A3P7C3C3	Macro domain-containing protein.	Uncharacterized protein.	0.798

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

6.25e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009132

Nucleoside diphosphate metabolic process

7 of 58

2.45

6.02

4.55e-13

GO:0072528

Pyrimidine-containing compound biosynthetic process

5 of 28

2.62

4.81

5.53e-10

GO:0009142

Nucleoside triphosphate biosynthetic process

5 of 29

2.6

4.78

6.02e-10

GO:0009141

Nucleoside triphosphate metabolic process

6 of 73

2.28

4.67

1.67e-10

GO:0090407

Organophosphate biosynthetic process

9 of 281

1.87

4.45

4.55e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

6 of 25

2.74

6.13

1.82e-12

GO:0019205

Nucleobase-containing compound kinase activity

6 of 29

2.68

6.04

2.01e-12

GO:0004550

Nucleoside diphosphate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0004017

Adenylate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 765

1.32

1.68

2.39e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36277867

(2022) Cold-induced denaturation of muscle proteins in hairtail (Trichiurus lepturus) during storage: Physicochemical and label-free based proteomics analyses.

3 of 52

2.12

1.26

0.0040

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5678

Purine metabolism

9 of 40

2.72

9.69

3.16e-20

CL:5732

Mixed, incl. CTP metabolic process, and Adenylate kinase activity

7 of 13

3.09

9.1

9.18e-18

CL:5673

Mixed, incl. Purine metabolism, and Metabolism of nucleotides

10 of 157

2.17

7.13

1.42e-18

CL:5748

Adenylate kinase activity, and ATP cone domain

4 of 5

3.27

4.99

8.16e-10

CL:5734

Nucleoside diphosphate kinase, and Purine ribonucleoside bisphosphate metabolic process

2 of 5

2.97

1.63

0.0011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pvm00230

Purine metabolism

9 of 76

2.44

8.5

2.35e-19

pvm00730

Thiamine metabolism

5 of 10

3.06

6.48

9.96e-13

pvm00240

Pyrimidine metabolism

5 of 36

2.51

5.02

1.24e-10

pvm00983

Drug metabolism - other enzymes

4 of 49

2.28

3.42

1.40e-07

pvm01100

Metabolic pathways

10 of 991

1.37

2.44

3.87e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-499943

Interconversion of nucleotide di- and triphosphates

5 of 21

2.74

4.93

4.73e-10

MAP-15869

Metabolism of nucleotides

6 of 104

2.12

4.02

1.80e-09

MAP-1430728

Metabolism

7 of 2301

0.85

0.61

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

7 of 411

1.59

2.59

2.75e-08

KW-0547

Nucleotide-binding

6 of 685

1.31

1.48

2.31e-05

KW-0067

ATP-binding

5 of 552

1.32

1.33

0.00015

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13207

AAA domain

3 of 5

3.14

2.93

4.83e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034907

Nucleoside diphosphate kinase-like domain

3 of 3

3.36

2.93

5.10e-06

IPR001564

Nucleoside diphosphate kinase

3 of 3

3.36

2.93

5.10e-06

IPR036850

Nucleoside diphosphate kinase-like domain superfamily

3 of 5

3.14

2.92

5.10e-06

IPR033690

Adenylate kinase, conserved site

3 of 5

3.14

2.92

5.10e-06

IPR000850

Adenylate kinase/UMP-CMP kinase

3 of 6

3.06

2.91

5.10e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00562

These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.

3 of 3

3.36

3.43

6.44e-07

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