A0A183TPP7 protein (Schistocephalus solidus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A183TPP7

WW domain-containing protein. (186 aa)

Predicted Functional Partners:

A0A183TC87

0.721

SSLN_LOCUS4113

0.706

A0A183T0V8

0.697

SSLN_LOCUS4077

0.697

SSLN_LOCUS7897

0.682

SSLN_LOCUS5730

0.673

SSLN_LOCUS2444

0.670

SSLN_LOCUS2595

0.670

SSLN_LOCUS6212

0.670

SSLN_LOCUS293

0.668

Your Current Organism:

Schistocephalus solidus

NCBI taxonomy Id: 70667
Other names: S. solidus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A183T0V8	A0A183TC87	A0A183T0V8	A0A183TC87	Roc domain-containing protein.	Uncharacterized protein.	0.580
A0A183T0V8	A0A183TPP7	A0A183T0V8	A0A183TPP7	Roc domain-containing protein.	WW domain-containing protein.	0.697
A0A183T0V8	SSLN_LOCUS2444	A0A183T0V8	A0A183SDZ6	Roc domain-containing protein.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.486
A0A183T0V8	SSLN_LOCUS2595	A0A183T0V8	A0A183SEE7	Roc domain-containing protein.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.486
A0A183T0V8	SSLN_LOCUS293	A0A183T0V8	A0A3P7BW91	Roc domain-containing protein.	Uncharacterized protein.	0.999
A0A183T0V8	SSLN_LOCUS4077	A0A183T0V8	A0A3P7BVZ0	Roc domain-containing protein.	Protein kinase domain-containing protein.	0.999
A0A183T0V8	SSLN_LOCUS5730	A0A183T0V8	A0A183SND2	Roc domain-containing protein.	WSC domain-containing protein.	0.705
A0A183T0V8	SSLN_LOCUS6212	A0A183T0V8	A0A183SPR4	Roc domain-containing protein.	Uncharacterized protein; Belongs to the intermediate filament family.	0.486
A0A183T0V8	SSLN_LOCUS7897	A0A183T0V8	A0A183SUJ9	Roc domain-containing protein.	Uncharacterized protein.	0.999
A0A183TC87	A0A183T0V8	A0A183TC87	A0A183T0V8	Uncharacterized protein.	Roc domain-containing protein.	0.580
A0A183TC87	A0A183TPP7	A0A183TC87	A0A183TPP7	Uncharacterized protein.	WW domain-containing protein.	0.721
A0A183TC87	SSLN_LOCUS4077	A0A183TC87	A0A3P7BVZ0	Uncharacterized protein.	Protein kinase domain-containing protein.	0.580
A0A183TC87	SSLN_LOCUS4113	A0A183TC87	A0A183SIR4	Uncharacterized protein.	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family.	0.967
A0A183TPP7	A0A183T0V8	A0A183TPP7	A0A183T0V8	WW domain-containing protein.	Roc domain-containing protein.	0.697
A0A183TPP7	A0A183TC87	A0A183TPP7	A0A183TC87	WW domain-containing protein.	Uncharacterized protein.	0.721
A0A183TPP7	SSLN_LOCUS2444	A0A183TPP7	A0A183SDZ6	WW domain-containing protein.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.670
A0A183TPP7	SSLN_LOCUS2595	A0A183TPP7	A0A183SEE7	WW domain-containing protein.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.670
A0A183TPP7	SSLN_LOCUS293	A0A183TPP7	A0A3P7BW91	WW domain-containing protein.	Uncharacterized protein.	0.668
A0A183TPP7	SSLN_LOCUS4077	A0A183TPP7	A0A3P7BVZ0	WW domain-containing protein.	Protein kinase domain-containing protein.	0.697
A0A183TPP7	SSLN_LOCUS4113	A0A183TPP7	A0A183SIR4	WW domain-containing protein.	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family.	0.706

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.804

expected number of edges:

12

PPI enrichment p-value:

2.46e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016052

Carbohydrate catabolic process

7 of 82

2.53

6.47

8.42e-14

GO:0019682

glyceraldehyde-3-phosphate metabolic process

4 of 8

3.3

5.04

6.78e-10

GO:0005975

Carbohydrate metabolic process

8 of 308

2.01

4.78

1.67e-12

GO:0006096

Glycolytic process

4 of 21

2.88

4.28

1.14e-08

GO:0019637

Organophosphate metabolic process

10 of 677

1.77

4.26

4.29e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

5 of 211

1.97

2.62

2.42e-06

GO:0016614

Oxidoreductase activity, acting on CH-OH group of donors

4 of 144

2.04

2.25

2.58e-05

GO:0052591

sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity

2 of 2

3.6

2.11

0.00016

GO:0008929

Methylglyoxal synthase activity

2 of 2

3.6

2.11

0.00016

GO:0004807

Triose-phosphate isomerase activity

2 of 2

3.6

2.11

0.00016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

3.6

3.7

2.12e-07

GO:0005829

Cytosol

7 of 1756

1.2

1.32

2.25e-05

GO:0005739

Mitochondrion

4 of 1201

1.12

0.64

0.0243

GO:0005737

Cytoplasm

11 of 10623

0.61

0.54

5.51e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:9211740

(1997) An estimate of divergence time of Parazoa and Eumetazoa and that of Cephalochordata and Vertebrata by aldolase and triose phosphate isomerase clocks.

2 of 2

3.6

1.5

0.0020

PMID:35193395

(2022) Novel protein from larval sponge cells, ilborin, is related to energy turnover and calcium binding and is conserved among marine invertebrates.

2 of 3

3.42

1.5

0.0020

PMID:34769888

(2021) Prevalence, Molecular Characterization and Antimicrobial Susceptibility of Clostridioides difficile Isolated from Pig Carcasses and Pork Products in Central Italy.

2 of 2

3.6

1.5

0.0020

PMID:34093163

(2021) Circular RNA circDUS2 Is a Potential Biomarker for Intracranial Aneurysm.

2 of 2

3.6

1.5

0.0020

PMID:31547548

(2019) Enzymes from Marine Polar Regions and Their Biotechnological Applications.

2 of 4

3.3

1.5

0.0020

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11044

Glycolysis, and Transketolase or transaldolase activity

5 of 12

3.22

6.02

9.38e-12

CL:11045

Glycolysis, and Phosphopyruvate hydratase complex

4 of 7

3.35

5.02

7.76e-10

CL:3319

Glycerol catabolic process, and Ethanolamine metabolic process

3 of 6

3.3

3.52

4.29e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aqu00051

Fructose and mannose metabolism

5 of 22

2.95

6.14

3.52e-12

aqu01200

Carbon metabolism

6 of 106

2.35

5.35

7.15e-12

aqu01230

Biosynthesis of amino acids

5 of 57

2.54

5.11

9.37e-11

aqu00010

Glycolysis / Gluconeogenesis

4 of 38

2.62

4.26

7.56e-09

aqu00030

Pentose phosphate pathway

3 of 22

2.73

3.32

6.76e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

4 of 20

2.9

4.29

1.16e-08

MAP-1483166

Synthesis of PA

4 of 29

2.74

4.08

2.23e-08

MAP-70263

Gluconeogenesis

4 of 55

2.46

3.48

1.98e-07

MAP-71387

Metabolism of carbohydrates

6 of 287

1.92

3.35

1.32e-08

MAP-70326

Glucose metabolism

4 of 65

2.39

3.34

3.13e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

3.6

3.81

1.34e-07

GOCC:0005737

Cytoplasm

11 of 5405

0.91

1.01

1.25e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

4 of 12

3.12

4.91

1.03e-09

KW-0312

Gluconeogenesis

2 of 3

3.42

2.29

7.46e-05

KW-0704

Schiff base

2 of 5

3.2

2.21

0.00010

KW-0456

Lyase

2 of 47

2.23

1.26

0.0044

KW-0413

Isomerase

2 of 57

2.14

1.21

0.0051

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00274

Fructose-bisphosphate aldolase class-I

2 of 2

3.6

1.79

0.00060

PF00121

Triosephosphate isomerase

2 of 2

3.6

1.79

0.00060

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 58

2.44

2.76

5.64e-06

IPR035990

Triosephosphate isomerase superfamily

2 of 2

3.6

1.72

0.00080

IPR029768

Fructose-bisphosphate aldolase class-I active site

2 of 2

3.6

1.72

0.00080

IPR000741

Fructose-bisphosphate aldolase, class-I

2 of 2

3.6

1.72

0.00080

IPR000652

Triosephosphate isomerase

2 of 2

3.6

1.72

0.00080

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About