A0A3P7DCH5 protein (Schistocephalus solidus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A3P7DCH5

Uncharacterized protein. (362 aa)

Predicted Functional Partners:

SSLN_LOCUS3923

0.714

A0A183TML7

0.704

SSLN_LOCUS4060

0.704

SSLN_LOCUS6723

0.669

SQSTM

0.654

A0A183T0V8

0.644

SSLN_LOCUS4077

0.644

PSA2

0.606

SSLN_LOCUS6064

0.595

A0A183T0K2

0.595

Your Current Organism:

Schistocephalus solidus

NCBI taxonomy Id: 70667
Other names: S. solidus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A183T0K2	A0A183T0V8	A0A183T0K2	A0A183T0V8	Uncharacterized protein.	Roc domain-containing protein.	0.783
A0A183T0K2	A0A183TML7	A0A183T0K2	A0A183TML7	Uncharacterized protein.	Uncharacterized protein.	0.749
A0A183T0K2	A0A3P7DCH5	A0A183T0K2	A0A3P7DCH5	Uncharacterized protein.	Uncharacterized protein.	0.595
A0A183T0K2	PSA2	A0A183T0K2	A0A0X3PI24	Uncharacterized protein.	Proteasome subunit alpha type.	0.785
A0A183T0K2	SQSTM	A0A183T0K2	A0A0V0JB45	Uncharacterized protein.	Sequestosome-1.	0.653
A0A183T0K2	SSLN_LOCUS4060	A0A183T0K2	A0A3P7C8N7	Uncharacterized protein.	Uncharacterized protein.	0.749
A0A183T0K2	SSLN_LOCUS4077	A0A183T0K2	A0A3P7BVZ0	Uncharacterized protein.	Protein kinase domain-containing protein.	0.783
A0A183T0K2	SSLN_LOCUS6723	A0A183T0K2	A0A183SR75	Uncharacterized protein.	bZIP_Maf domain-containing protein.	0.703
A0A183T0V8	A0A183T0K2	A0A183T0V8	A0A183T0K2	Roc domain-containing protein.	Uncharacterized protein.	0.783
A0A183T0V8	A0A183TML7	A0A183T0V8	A0A183TML7	Roc domain-containing protein.	Uncharacterized protein.	0.998
A0A183T0V8	A0A3P7DCH5	A0A183T0V8	A0A3P7DCH5	Roc domain-containing protein.	Uncharacterized protein.	0.644
A0A183T0V8	PSA2	A0A183T0V8	A0A0X3PI24	Roc domain-containing protein.	Proteasome subunit alpha type.	0.643
A0A183T0V8	SQSTM	A0A183T0V8	A0A0V0JB45	Roc domain-containing protein.	Sequestosome-1.	0.778
A0A183T0V8	SSLN_LOCUS3923	A0A183T0V8	A0A183SI75	Roc domain-containing protein.	AMP-binding domain-containing protein.	0.471
A0A183T0V8	SSLN_LOCUS4060	A0A183T0V8	A0A3P7C8N7	Roc domain-containing protein.	Uncharacterized protein.	0.998
A0A183T0V8	SSLN_LOCUS4077	A0A183T0V8	A0A3P7BVZ0	Roc domain-containing protein.	Protein kinase domain-containing protein.	0.999
A0A183T0V8	SSLN_LOCUS6064	A0A183T0V8	A0A183SPB6	Roc domain-containing protein.	Uncharacterized protein.	0.783
A0A183T0V8	SSLN_LOCUS6723	A0A183T0V8	A0A183SR75	Roc domain-containing protein.	bZIP_Maf domain-containing protein.	0.758
A0A183TML7	A0A183T0K2	A0A183TML7	A0A183T0K2	Uncharacterized protein.	Uncharacterized protein.	0.749
A0A183TML7	A0A183T0V8	A0A183TML7	A0A183T0V8	Uncharacterized protein.	Roc domain-containing protein.	0.998

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.947

expected number of edges:

12

PPI enrichment p-value:

2.31e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044205

De novo UMP biosynthetic process

4 of 8

2.73

3.3

7.37e-07

GO:0006207

De novo pyrimidine nucleobase biosynthetic process

4 of 12

2.55

3.24

7.45e-07

GO:0042128

Nitrate assimilation

2 of 7

2.48

1.36

0.0032

GO:0044281

Small molecule metabolic process

7 of 1150

0.81

0.63

0.0024

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

3.03

1.18

0.0076

GO:0004152

Dihydroorotate dehydrogenase activity

2 of 2

3.03

1.18

0.0076

GO:0004590

orotidine-5-phosphate decarboxylase activity

2 of 3

2.85

1.17

0.0076

GO:0043546

Molybdopterin cofactor binding

2 of 5

2.63

1.16

0.0076

GO:0030151

Molybdenum ion binding

2 of 9

2.38

1.15

0.0076

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10878

De novo UMP biosynthetic process, and Purine nucleobase transmembrane transporter activity

6 of 10

2.81

6.17

1.95e-12

CL:10881

De novo UMP biosynthetic process

3 of 5

2.81

2.86

5.50e-06

CL:10002

Molybdenum ion binding, and Prosthetic group metabolic process

3 of 15

2.33

2.17

7.36e-05

CL:10004

Oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor, and Nitronate monooxygenase

2 of 6

2.55

1.37

0.0031

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

plj00240

Pyrimidine metabolism

3 of 25

2.11

1.85

0.00024

plj00910

Nitrogen metabolism

2 of 16

2.13

1.13

0.0074

plj01100

Metabolic pathways

6 of 1076

0.77

0.55

0.0075

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-500753

Pyrimidine biosynthesis

4 of 7

2.79

3.71

1.30e-07

MAP-8956320

Nucleotide biosynthesis

4 of 23

2.27

2.78

3.43e-06

MAP-15869

Metabolism of nucleotides

4 of 80

1.73

1.65

0.00024

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01180

Dihydroorotate dehydrogenase

2 of 2

3.03

1.28

0.0050

PF03404

Mo-co oxidoreductase dimerisation domain

2 of 5

2.63

1.13

0.0087

PF00174

Oxidoreductase molybdopterin binding domain

2 of 5

2.63

1.13

0.0087

PF00970

Oxidoreductase FAD-binding domain

2 of 10

2.33

1.01

0.0137

PF00175

Oxidoreductase NAD-binding domain

2 of 18

2.07

0.81

0.0314

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

3 of 21

2.18

1.3

0.0036

IPR001199

Cytochrome b5-like heme/steroid binding domain

3 of 21

2.18

1.3

0.0036

IPR005720

Dihydroorotate dehydrogenase domain

2 of 2

3.03

1.29

0.0047

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

2 of 5

2.63

1.05

0.0123

IPR008335

Eukaryotic molybdopterin oxidoreductase

2 of 5

2.63

1.05

0.0123

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 22

2.16

1.72

0.00048

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