STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A139WEY0Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (1187 aa)    
Predicted Functional Partners:
PlexA
Plexin A.
    
 0.609
D6W698_TRICA
Transcription factor Sp3-like Protein.
      
 0.570
D6WLD8_TRICA
Intraflagellar transport protein 80 homolog-like Protein.
      
 0.570
D6WTL6_TRICA
Carbohydrate sulfotransferase.
      
 0.570
D6W8H2_TRICA
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8.
    
 0.542
D6W6K8_TRICA
Leucine-rich repeats and immunoglobulin-like domains protein 3.
     
 0.484
D6WYC2_TRICA
Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.
     
 0.482
D6W685_TRICA
Leucine-rich repeat-containing protein 15-like Protein.
    
 0.456
D2A3A2_TRICA
Leucine-rich repeats and immunoglobulin-like domains protein 3.
    
 0.455
A0A139WH15
Dystrophin, isoform D-like Protein.
      
 0.450
Your Current Organism:
Tribolium castaneum
NCBI taxonomy Id: 7070
Other names: T. castaneum, red flour beetle, rust-red flour beetle
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.