pta_1 protein (Jeotgalibaca dankookensis) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

pta_1

Phosphate acetyltransferase. (325 aa)

Predicted Functional Partners:

ackA

0.993

adhE_3

0.947

pdhC_1

0.926

pdhC_2

0.926

pox5

0.925

pflB

0.925

adhE_2

0.924

acyP

0.923

thlA

0.923

AQS53516.1

0.921

Your Current Organism:

Jeotgalibaca dankookensis

NCBI taxonomy Id: 708126
Other names: J. dankookensis, JCM 19215, Jeotgalibaca dankookensis Lee et al. 2014, KCCM 90229, Trichococcus sp. EX-07, strain EX-07

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQS53516.1	adhE_3	BW727_101149	BW727_100585	NAD-dependent malic enzyme.	Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.519
AQS53516.1	pflB	BW727_101149	BW727_101939	NAD-dependent malic enzyme.	Formate acetyltransferase.	0.931
AQS53516.1	pox5	BW727_101149	BW727_101040	NAD-dependent malic enzyme.	Pyruvate oxidase; Belongs to the TPP enzyme family.	0.937
AQS53516.1	pta_1	BW727_101149	BW727_101283	NAD-dependent malic enzyme.	Phosphate acetyltransferase.	0.921
ackA	acyP	BW727_100480	BW727_100611	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Acylphosphatase.	0.918
ackA	adhE_2	BW727_100480	BW727_100369	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Aldehyde-alcohol dehydrogenase.	0.423
ackA	adhE_3	BW727_100480	BW727_100585	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.600
ackA	pflB	BW727_100480	BW727_101939	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Formate acetyltransferase.	0.453
ackA	pox5	BW727_100480	BW727_101040	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Pyruvate oxidase; Belongs to the TPP enzyme family.	0.935
ackA	pta_1	BW727_100480	BW727_101283	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Phosphate acetyltransferase.	0.993
acyP	ackA	BW727_100611	BW727_100480	Acylphosphatase.	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	0.918
acyP	adhE_3	BW727_100611	BW727_100585	Acylphosphatase.	Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.444
acyP	pox5	BW727_100611	BW727_101040	Acylphosphatase.	Pyruvate oxidase; Belongs to the TPP enzyme family.	0.900
acyP	pta_1	BW727_100611	BW727_101283	Acylphosphatase.	Phosphate acetyltransferase.	0.923
adhE_2	ackA	BW727_100369	BW727_100480	Aldehyde-alcohol dehydrogenase.	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	0.423
adhE_2	adhE_3	BW727_100369	BW727_100585	Aldehyde-alcohol dehydrogenase.	Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.932
adhE_2	pdhC_1	BW727_100369	BW727_100509	Aldehyde-alcohol dehydrogenase.	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex.	0.916
adhE_2	pflB	BW727_100369	BW727_101939	Aldehyde-alcohol dehydrogenase.	Formate acetyltransferase.	0.941
adhE_2	pta_1	BW727_100369	BW727_101283	Aldehyde-alcohol dehydrogenase.	Phosphate acetyltransferase.	0.924
adhE_2	thlA	BW727_100369	BW727_101415	Aldehyde-alcohol dehydrogenase.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.919

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009097

Isoleucine biosynthetic process

7 of 14

2.26

5.34

2.79e-12

GO:0009099

Valine biosynthetic process

5 of 10

2.26

3.86

1.31e-08

GO:1901607

Alpha-amino acid biosynthetic process

10 of 104

1.55

3.16

1.07e-12

GO:0046394

Carboxylic acid biosynthetic process

11 of 166

1.39

2.55

1.07e-12

GO:0043650

Dicarboxylic acid biosynthetic process

3 of 19

1.76

1.4

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000287

Magnesium ion binding

5 of 65

1.45

1.34

0.00046

GO:0019842

Vitamin binding

4 of 46

1.5

1.14

0.0026

GO:0015930

Glutamate synthase activity

2 of 2

2.56

1.12

0.0090

GO:0004455

Ketol-acid reductoisomerase activity

2 of 2

2.56

1.12

0.0090

GO:0050661

NADP binding

3 of 22

1.7

1.01

0.0090

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005948

Acetolactate synthase complex

2 of 2

2.56

1.39

0.0028

GO:0005829

Cytosol

7 of 324

0.9

0.76

0.00080

GO:0005737

Cytoplasm

9 of 1245

0.42

0.29

0.0348

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:993

Branched-chain amino acid metabolic process

6 of 23

1.98

3.5

1.00e-08

CL:924

Branched-chain amino acid metabolic process, and Aspartate family amino acid biosynthetic process

8 of 58

1.7

3.32

2.20e-10

CL:923

Alpha-amino acid biosynthetic process, and Dicarboxylic acid metabolic process

9 of 84

1.59

3.09

5.47e-11

CL:996

Branched-chain amino acid metabolic process

4 of 17

1.94

2.12

3.68e-05

CL:810

Glutamate biosynthetic process, and Ammonia ligase activity

2 of 5

2.17

0.87

0.0239

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00290

Valine, leucine and isoleucine biosynthesis

7 of 22

2.07

4.63

1.56e-11

map00770

Pantothenate and CoA biosynthesis

6 of 21

2.02

3.94

8.68e-10

map01210

2-Oxocarboxylic acid metabolism

6 of 51

1.63

2.58

7.73e-08

map01230

Biosynthesis of amino acids

10 of 159

1.36

2.38

1.56e-11

map00660

C5-Branched dibasic acid metabolism

2 of 10

1.87

1.09

0.0074

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005948

Acetolactate synthase complex

2 of 4

2.26

1.07

0.0102

GOCC:0005737

Cytoplasm

10 of 946

0.59

0.47

0.0014

GOCC:0005622

Intracellular

11 of 1345

0.48

0.39

0.0014

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

4 of 14

2.02

2.3

1.87e-05

KW-0412

Isoleucine biosynthesis

2 of 3

2.39

1.26

0.0047

KW-0663

Pyridoxal phosphate

3 of 40

1.44

0.92

0.0091

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04898

Glutamate synthase central domain

2 of 2

2.56

0.85

0.0286

PF02776

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

2 of 2

2.56

0.85

0.0286

PF01645

Conserved region in glutamate synthase

2 of 2

2.56

0.85

0.0286

PF01493

GXGXG motif

2 of 2

2.56

0.85

0.0286

PF01450

Acetohydroxy acid isomeroreductase, catalytic domain

2 of 2

2.56

0.85

0.0286

(more ...)

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