STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADR32696.1Aminoglycoside phosphotransferase; COGs: COG2334 Putative homoserine kinase type II (protein kinase fold); InterPro IPR002575; KEGG: ant:Arnit_1841 aminoglycoside phosphotransferase; PFAM: aminoglycoside phosphotransferase; SPTR: Aminoglycoside phosphotransferase; PFAM: Phosphotransferase enzyme family. (254 aa)    
Predicted Functional Partners:
ADR34958.1
COGs: COG0460 Homoserine dehydrogenase; InterProIPR019811: IPR016204: IPR005106: IPR001342: IPR 002912; KEGG: tdn:Suden_1904 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; SPTR: Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain.
 
  
 0.941
ADR33682.1
COGs: COG0498 Threonine synthase; InterPro IPR001926: IPR004450: IPR000634; KEGG: tdn:Suden_0789 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: Threonine synthase; SPTR: L-threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase.
    
 0.922
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
     
  0.900
cobS
Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
    0.818
ADR32695.1
COGs: COG2038 NaMN:DMB phosphoribosyltransferase; InterPro IPR002805: IPR003200; KEGG: ant:Arnit_1840 hypothetical protein; PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; SPTR: Putative uncharacterized protein; PFAM: Phosphoribosyltransferase; TIGRFAM: conserved hypothetical protein TIGR00303.
  
    0.817
ADR32809.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
  0.815
ilvE
Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
     
 0.814
cobQ
Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
    0.813
ADR34564.1
Aminotransferase class I and II; COGs: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; InterPro IPR004839; KEGG: tdn:Suden_0481 aminotransferase, class I and II; PFAM: aminotransferase class I and II; SPTR: Aminotransferase, class I and II; PFAM: Aminotransferase class I and II.
   
 
  0.810
ADR33456.1
COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR000277: IPR006235; KEGG: nis:NIS_1278 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase.
    
  0.807
Your Current Organism:
Sulfuricurvum kujiense
NCBI taxonomy Id: 709032
Other names: S. kujiense DSM 16994, Sulfuricurvum kujiense DSM 16994, Sulfuricurvum kujiense YK-1, Sulfuricurvum kujiense str. DSM 16994, Sulfuricurvum kujiense strain DSM 16994
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