STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADR33405.1DNA mismatch repair protein MutS domain protein; COGs: COG0249 Mismatch repair ATPase (MutS family); InterPro IPR000432; KEGG: tdn:Suden_1446 DNA mismatch repair protein MutS-like; PFAM: DNA mismatch repair protein MutS domain protein; SMART: DNA mismatch repair protein MutS domain protein; SPTR: MutS domain III family; PFAM: MutS domain V; MutS domain III. (674 aa)    
Predicted Functional Partners:
mutS2
Smr protein/MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
 
 
0.937
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.928
ADR33560.1
MutS III domain protein; COGs: COG0249 Mismatch repair ATPase (MutS family); InterPro IPR007696: IPR000432: IPR007695: IPR002711; KEGG: sdl:Sdel_0624 DNA mismatch repair protein MutS domain protein; PFAM: MutS III domain protein; DNA mismatch repair protein MutS domain protein; HNH endonuclease; SMART: DNA mismatch repair protein MutS domain protein; MutS III domain protein; SPTR: DNA mismatch repair protein MutS domain protein; PFAM: HNH endonuclease; MutS domain V; MutS domain I; MutS domain III.
  
  
 
0.917
ADR32670.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.915
dapE
Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.
  
    0.776
ADR33408.1
Endoribonuclease L-PSP; COGs: COG0251 Putative translation initiation inhibitor yjgF family; InterPro IPR006175: IPR019897: IPR006056; KEGG: sdl:Sdel_0496 endoribonuclease L-PSP; PFAM: Endoribonuclease L-PSP; SPTR: Endoribonuclease L-PSP; TIGRFAM: endoribonuclease L-PSP; PFAM: Endoribonuclease L-PSP; TIGRFAM: endoribonuclease L-PSP, putative.
       0.678
ADR33407.1
KEGG: tdn:Suden_1900 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function, DUF255.
       0.675
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.591
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
 
  
 0.538
ADR33404.1
PAS sensor protein; InterPro IPR000014: IPR001610: IPR013767; KEGG: nis:NIS_0548 signal transduction sensor histidine kinase; PFAM: PAS fold domain protein; SMART: PAC repeat-containing protein; PAS domain containing protein; SPTR: Signal transduction sensor histidine kinase; TIGRFAM: PAS sensor protein; PFAM: PAS fold; TIGRFAM: PAS domain S-box.
       0.529
Your Current Organism:
Sulfuricurvum kujiense
NCBI taxonomy Id: 709032
Other names: S. kujiense DSM 16994, Sulfuricurvum kujiense DSM 16994, Sulfuricurvum kujiense YK-1, Sulfuricurvum kujiense str. DSM 16994, Sulfuricurvum kujiense strain DSM 16994
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