STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADR33578.1Two component transcriptional regulator, winged helix family; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789: IPR001867; KEGG: wsu:WS1954 signal transduction regulatory protein; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; SMART: response regulator receiver; SPTR: Two component transcriptional regulator, winged helix family, putative; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (225 aa)    
Predicted Functional Partners:
ADR33577.1
COGs: COG3920 Signal transduction histidine kinase; InterPro IPR011622: IPR011623: IPR011495: IPR003594; KEGG: nis:NIS_0514 hypothetical protein; PFAM: Diverse 7TM receptor transmembrane region; Diverse 7TM receptor extracellular region 2; histidine kinase dimerisation/phosphoacceptor; ATP-binding region ATPase domain protein; SPTR: Putative uncharacterized protein; PFAM: Histidine kinase; 7TM diverse intracellular signalling; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; 7TMR-DISM extracellular 2.
 
   
 0.913
ADR34300.1
COGs: COG0642 Signal transduction histidine kinase; InterProIPR003660: IPR013656: IPR003661: IPR003594: IPR 001789: IPR005467: IPR000014: IPR000700: IPR004358; KEGG: ant:Arnit_0359 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; histidine kinase HAMP region domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; response regulator receiver; SPTR: Multi-sensor hybrid histidine kinase; T [...]
 
 0.886
ADR34682.1
COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014: IPR005467: IPR001789: IPR000700: IPR 006189: IPR008207: IPR001610: IPR003661: IPR003594: IPR004358:I PR013767: IPR013656; KEGG: azo:azo2482 putative hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; CHASE domain protein; PAS fold domain protein; PAS fold-4 domain protein; response regulator receiver; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; PAC repeat-containing [...]
  
 
 0.882
ADR34103.1
COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014: IPR013656: IPR013655: IPR013767: IPR 003661: IPR003594: IPR004358: IPR001610: IPR005467: IPR000700; KEGG: ant:Arnit_0391 multi-sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold-4 domain protein; PAS fold-3 domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; PAS domain containing protein; PAC repeat-containing protein; histidine kinase A domain protein; SPTR: Multi-sensor signal transduction hi [...]
 
 
 0.846
ADR34657.1
Hpt sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467: IPR001789: IPR008207: IPR003661: IPR 003594: IPR004358; KEGG: tdn:Suden_0617 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; SPTR: Sensor protein GacS; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; [...]
 
 
 0.832
ADR34129.1
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003660: IPR003661: IPR003594: IPR005467; KEGG: abu:Abu_2326 two-component sensor histidine kinase; PFAM: histidine kinase HAMP region domain protein; histidine kinase A domain protein; ATP-binding region ATPase domain protein; SMART: histidine kinase HAMP region domain protein; histidine kinase A domain protein; ATP-binding region ATPase domain protein; SPTR: Two-component sensor histidine kinase; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
  
   0.716
ADR34330.1
Response regulator receiver sensor signal transduction histidine kinase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789: IPR003594: IPR005467; KEGG: ant:Arnit_1053 response regulator receiver sensor signal transduction histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; SPTR: Response regulator receiver sensor signal transduction histidine kinase; PFAM: Response regulator receiver domain; Histidine kinas [...]
 
 
 0.702
ADR34288.1
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR001789: IPR003661: IPR003594: IPR005467; KEGG: nis:NIS_0528 two-component sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SMART: response regulator receiver; histidine kinase A domain protein; ATP-binding region ATPase domain protein; SPTR: Histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain.
 
 
 0.653
ADR33973.1
Transcriptional regulator, NifA subfamily, Fis Family; COGs: COG3604 Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains; InterProIPR003018: IPR002078: IPR002197: IPR020441: IPR 003593; KEGG: ant:Arnit_0031 NifA subfamily transcriptional regulator; PFAM: sigma-54 factor interaction domain-containing protein; GAF domain protein; helix-turn-helix Fis-type; SMART: AAA ATPase; GAF domain protein; SPTR: Transcriptional regulator, NifA subfamily, Fis Family; PFAM: GAF domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain; TIGRFAM: Nif-spec [...]
 
  
 
 0.626
ADR34444.1
Integral membrane sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR003661: IPR003594: IPR001789: IPR005467: IPR 004358; KEGG: hch:HCH_00309 signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; SPTR: Signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; [...]
 
 0.603
Your Current Organism:
Sulfuricurvum kujiense
NCBI taxonomy Id: 709032
Other names: S. kujiense DSM 16994, Sulfuricurvum kujiense DSM 16994, Sulfuricurvum kujiense YK-1, Sulfuricurvum kujiense str. DSM 16994, Sulfuricurvum kujiense strain DSM 16994
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.