STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
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Experiments
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[Homology]
Score
ADR35110.1Diguanylate cyclase; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000644: IPR000160; KEGG: tbd:Tbd_1953 diguanylate cyclase; PFAM: GGDEF domain containing protein; CBS domain containing protein; PRIAM: Diguanylate kinase; SMART: GGDEF domain containing protein; CBS domain containing protein; SPTR: Diguanylate cyclase; TIGRFAM: diguanylate cyclase; PFAM: CBS domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (445 aa)    
Predicted Functional Partners:
ADR35109.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000644: IPR013767: IPR013656: IPR000160: IPR 001633: IPR000014: IPR000700; KEGG: slt:Slit_2517 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; CBS domain containing protein; PAS fold domain protein; PAS fold-4 domain protein; SMART: EAL domain protein; GGDEF domain containing protein; PAS domain containing protein; CBS domain containing protein; [...]
 
 
0.902
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 
 0.884
ADR34682.1
COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014: IPR005467: IPR001789: IPR000700: IPR 006189: IPR008207: IPR001610: IPR003661: IPR003594: IPR004358:I PR013767: IPR013656; KEGG: azo:azo2482 putative hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; CHASE domain protein; PAS fold domain protein; PAS fold-4 domain protein; response regulator receiver; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; PAC repeat-containing [...]
 
 
 0.840
ribB
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
  
 
 0.809
ADR34300.1
COGs: COG0642 Signal transduction histidine kinase; InterProIPR003660: IPR013656: IPR003661: IPR003594: IPR 001789: IPR005467: IPR000014: IPR000700: IPR004358; KEGG: ant:Arnit_0359 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; histidine kinase HAMP region domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; response regulator receiver; SPTR: Multi-sensor hybrid histidine kinase; T [...]
 
 
 0.768
ADR34657.1
Hpt sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467: IPR001789: IPR008207: IPR003661: IPR 003594: IPR004358; KEGG: tdn:Suden_0617 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; SPTR: Sensor protein GacS; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; [...]
 
  
 0.751
ADR33076.1
Diguanylate cyclase/phosphodiesterase with extracellular sensor; COGs: COG2200 FOG: EAL domain; InterPro IPR000160: IPR003660: IPR001633; KEGG: cbe:Cbei_2527 diguanylate cyclase/phosphodiesterase; PFAM: EAL domain protein; GGDEF domain containing protein; histidine kinase HAMP region domain protein; SMART: EAL domain protein; GGDEF domain containing protein; SPTR: Ggdef family protein; TIGRFAM: diguanylate cyclase; PFAM: EAL domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
    0.701
ADR32824.1
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683; KEGG: mag:amb3807 dehydrogenase and related protein; PFAM: oxidoreductase domain protein; SPTR: Predicted dehydrogenase and related protein; PFAM: Oxidoreductase family, NAD-binding Rossmann fold.
  
 
 0.685
ADR34784.1
dTDP-glucose 4,6-dehydratase; COGs: COG1088 dTDP-D-glucose 4 6-dehydratase; InterPro IPR005888: IPR001509; KEGG: sdl:Sdel_1797 dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: dTDP-glucose 4,6-dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.
  
  
 0.685
purH
IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR002695: IPR013982: IPR011607; KEGG: tdn:Suden_0550 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecar [...]
  
  
 0.666
Your Current Organism:
Sulfuricurvum kujiense
NCBI taxonomy Id: 709032
Other names: S. kujiense DSM 16994, Sulfuricurvum kujiense DSM 16994, Sulfuricurvum kujiense YK-1, Sulfuricurvum kujiense str. DSM 16994, Sulfuricurvum kujiense strain DSM 16994
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