STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
clpP-2ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (198 aa)    
Predicted Functional Partners:
clpX
ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
 
 0.941
ADR34178.1
ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
 
 0.940
tig
Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
 
  
 0.913
def
Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
 
  
 0.901
ADR33238.1
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176: IPR003959: IPR013093: IPR019489: IPR 001270: IPR018368: IPR003593; KEGG: tdn:Suden_0520 AAA ATPase; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATP-dependent Clp protease, ATP-binding subunit ClpB; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: ATP-depen [...]
  
 
 0.887
ADR34591.1
ATP-dependent Clp protease, ATP-binding subunit clpA; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR013461: IPR018062: IPR001270: IPR003593: IPR 004176: IPR003959: IPR013093: IPR019489; KEGG: nis:NIS_0380 ATP-dependent Clp protease, ATP-binding subunit ClpA; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATP-dependent Clp protease ATP-binding subunit ClpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA domain (Cdc48 subfamily); Clp amino terminal [...]
  
 
 0.887
ADR35186.1
Diguanylate cyclase; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000160; KEGG: tdn:Suden_2035 diguanylate cyclase; PFAM: GGDEF domain containing protein; SMART: GGDEF domain containing protein; SPTR: Diguanylate cyclase; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
       0.775
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
   
 
 0.683
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 
 0.669
ribB
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
   
 
 0.658
Your Current Organism:
Sulfuricurvum kujiense
NCBI taxonomy Id: 709032
Other names: S. kujiense DSM 16994, Sulfuricurvum kujiense DSM 16994, Sulfuricurvum kujiense YK-1, Sulfuricurvum kujiense str. DSM 16994, Sulfuricurvum kujiense strain DSM 16994
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