STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PPAEPhenoloxidase-activating enzyme heavy chain; Endopeptidase with selective post-Arg cleavage site. Activates prophenoloxidase. Has a probable role in the melanization process as part of the innate immune response (Probable). (441 aa)    
Predicted Functional Partners:
BGRP1
Beta-1,3-glucan-binding protein; Involved in the recognition of invading micro-organisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade.
    
 0.543
Serpin-3
SERPIN domain-containing protein; Belongs to the serpin family.
    
 0.541
H9JTC9_BOMMO
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
     0.532
H9JTB5_BOMMO
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
     0.529
H9J0I8_BOMMO
Peptidase S1 domain-containing protein.
  
     0.520
H9J0R7_BOMMO
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
     0.518
PPO1
Phenoloxidase subunit 1; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone.
      
 0.509
PPO2
Phenoloxidase subunit 2; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone.
      
 0.509
Q1HPY5_BOMMO
Scolexin; Belongs to the peptidase S1 family.
  
   
 0.483
H9JG66_BOMMO
Peptidase S1 domain-containing protein.
  
     0.462
Your Current Organism:
Bombyx mori
NCBI taxonomy Id: 7091
Other names: B. mori, domestic silkworm, silk moth, silkworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.