Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lepATranslation elongation factor LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (601 aa)    
Predicted Functional Partners:
rplM
LSU ribosomal protein L13p; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
 
 
 0.954
rplT
LSU ribosomal protein L20p; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
 
 
 0.944
rpsI
SSU ribosomal protein S9p; Belongs to the universal ribosomal protein uS9 family.
 
 
 0.943
rplO
LSU ribosomal protein L15p; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
  
 
 0.943
rplC
LSU ribosomal protein L3p; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
  
 
 0.943
rpsB
SSU ribosomal protein S2p; Belongs to the universal ribosomal protein uS2 family.
  
 
 0.936
rplA
LSU ribosomal protein L1p; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
  
 
 0.930
rpsP
SSU ribosomal protein S16p; Belongs to the bacterial ribosomal protein bS16 family.
 
 
 0.929
rpmA
LSU ribosomal protein L27p; Belongs to the bacterial ribosomal protein bL27 family.
  
 
 0.926
rpsO
SSU ribosomal protein S15p; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
 
 
 0.926
Your Current Organism:
Bradyrhizobiaceae bacterium SG6C
NCBI taxonomy Id: 709797
Other names: B. bacterium SG-6C, Bradyrhizobiaceae bacterium SG-6C
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.