| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSIRO_0997 | CSIRO_1512 | CSIRO_0997 | CSIRO_1512 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.926 |
| CSIRO_0997 | CSIRO_2169 | CSIRO_0997 | CSIRO_2169 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.980 |
| CSIRO_0997 | CSIRO_3304 | CSIRO_0997 | CSIRO_3304 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.911 |
| CSIRO_0997 | CSIRO_3914 | CSIRO_0997 | CSIRO_3914 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III methyltransferase/ uroporphyrinogen-III synthase; Bifunctional. | 0.768 |
| CSIRO_0997 | cysC | CSIRO_0997 | CSIRO_1510 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Sulfate adenylyltransferase subunit 1/ adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.643 |
| CSIRO_1511 | CSIRO_1512 | CSIRO_1511 | CSIRO_1512 | Sulfate adenylyltransferase subunit 2. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.977 |
| CSIRO_1511 | CSIRO_1513 | CSIRO_1511 | CSIRO_1513 | Sulfate adenylyltransferase subunit 2. | Hypothetical protein. | 0.617 |
| CSIRO_1511 | CSIRO_1514 | CSIRO_1511 | CSIRO_1514 | Sulfate adenylyltransferase subunit 2. | Sulfite reductase (NADPH) hemoprotein beta-component. | 0.966 |
| CSIRO_1511 | CSIRO_1516 | CSIRO_1511 | CSIRO_1516 | Sulfate adenylyltransferase subunit 2. | Phosphoadenylyl-sulfate reductase/ adenylyl-sulfate reductase; Reduction of activated sulfate into sulfite. | 0.997 |
| CSIRO_1511 | CSIRO_2919 | CSIRO_1511 | CSIRO_2919 | Sulfate adenylyltransferase subunit 2. | Ferredoxin--nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.942 |
| CSIRO_1511 | cysC | CSIRO_1511 | CSIRO_1510 | Sulfate adenylyltransferase subunit 2. | Sulfate adenylyltransferase subunit 1/ adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.999 |
| CSIRO_1512 | CSIRO_0997 | CSIRO_1512 | CSIRO_0997 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.926 |
| CSIRO_1512 | CSIRO_1511 | CSIRO_1512 | CSIRO_1511 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfate adenylyltransferase subunit 2. | 0.977 |
| CSIRO_1512 | CSIRO_1513 | CSIRO_1512 | CSIRO_1513 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Hypothetical protein. | 0.937 |
| CSIRO_1512 | CSIRO_1514 | CSIRO_1512 | CSIRO_1514 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfite reductase (NADPH) hemoprotein beta-component. | 0.995 |
| CSIRO_1512 | CSIRO_1516 | CSIRO_1512 | CSIRO_1516 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Phosphoadenylyl-sulfate reductase/ adenylyl-sulfate reductase; Reduction of activated sulfate into sulfite. | 0.992 |
| CSIRO_1512 | CSIRO_2169 | CSIRO_1512 | CSIRO_2169 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
| CSIRO_1512 | CSIRO_2919 | CSIRO_1512 | CSIRO_2919 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Ferredoxin--nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.984 |
| CSIRO_1512 | CSIRO_3304 | CSIRO_1512 | CSIRO_3304 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.979 |
| CSIRO_1512 | CSIRO_3914 | CSIRO_1512 | CSIRO_3914 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | uroporphyrinogen-III methyltransferase/ uroporphyrinogen-III synthase; Bifunctional. | 0.930 |