| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSIRO_2812 | CSIRO_3706 | CSIRO_2812 | CSIRO_3706 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Glycine cleavage system T protein. | 0.904 |
| CSIRO_2812 | folD | CSIRO_2812 | CSIRO_1019 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.661 |
| CSIRO_2812 | gcvH | CSIRO_2812 | CSIRO_3707 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.915 |
| CSIRO_2812 | gcvP | CSIRO_2812 | CSIRO_3708 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.914 |
| CSIRO_2812 | glyA | CSIRO_2812 | CSIRO_3297 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.849 |
| CSIRO_2812 | purH | CSIRO_2812 | CSIRO_0983 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | IMP cyclohydrolase/ phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional. | 0.416 |
| CSIRO_3706 | CSIRO_2812 | CSIRO_3706 | CSIRO_2812 | Glycine cleavage system T protein. | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.904 |
| CSIRO_3706 | folD | CSIRO_3706 | CSIRO_1019 | Glycine cleavage system T protein. | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.857 |
| CSIRO_3706 | gcvH | CSIRO_3706 | CSIRO_3707 | Glycine cleavage system T protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| CSIRO_3706 | gcvP | CSIRO_3706 | CSIRO_3708 | Glycine cleavage system T protein. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| CSIRO_3706 | glyA | CSIRO_3706 | CSIRO_3297 | Glycine cleavage system T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.992 |
| CSIRO_3706 | purD | CSIRO_3706 | CSIRO_0435 | Glycine cleavage system T protein. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.758 |
| CSIRO_3706 | purH | CSIRO_3706 | CSIRO_0983 | Glycine cleavage system T protein. | IMP cyclohydrolase/ phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional. | 0.762 |
| CSIRO_3706 | purN | CSIRO_3706 | CSIRO_2644 | Glycine cleavage system T protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.729 |
| folD | CSIRO_2812 | CSIRO_1019 | CSIRO_2812 | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.661 |
| folD | CSIRO_3706 | CSIRO_1019 | CSIRO_3706 | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein. | 0.857 |
| folD | gcvH | CSIRO_1019 | CSIRO_3707 | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.788 |
| folD | gcvP | CSIRO_1019 | CSIRO_3708 | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.919 |
| folD | glyA | CSIRO_1019 | CSIRO_3297 | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.962 |
| folD | purA | CSIRO_1019 | CSIRO_0151 | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.810 |
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