| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSIRO_1448 | CSIRO_2876 | CSIRO_1448 | CSIRO_2876 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.874 |
| CSIRO_1448 | CSIRO_3008 | CSIRO_1448 | CSIRO_3008 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine synthase B. | 0.874 |
| CSIRO_1448 | CSIRO_3597 | CSIRO_1448 | CSIRO_3597 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine acetyltransferase. | 0.824 |
| CSIRO_1448 | CSIRO_3945 | CSIRO_1448 | CSIRO_3945 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine--glyoxylate aminotransferase. | 0.770 |
| CSIRO_1448 | CSIRO_4019 | CSIRO_1448 | CSIRO_4019 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoserine phosphatase. | 0.852 |
| CSIRO_1448 | cysS | CSIRO_1448 | CSIRO_2459 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.575 |
| CSIRO_1448 | glyA | CSIRO_1448 | CSIRO_3297 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.857 |
| CSIRO_1448 | metZ | CSIRO_1448 | CSIRO_1266 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-acetylhomoserine sulfhydrylase/ O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.946 |
| CSIRO_2876 | CSIRO_1448 | CSIRO_2876 | CSIRO_1448 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.874 |
| CSIRO_2876 | CSIRO_3008 | CSIRO_2876 | CSIRO_3008 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cysteine synthase B. | 0.805 |
| CSIRO_2876 | CSIRO_3597 | CSIRO_2876 | CSIRO_3597 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Serine acetyltransferase. | 0.990 |
| CSIRO_2876 | CSIRO_3945 | CSIRO_2876 | CSIRO_3945 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Serine--glyoxylate aminotransferase. | 0.680 |
| CSIRO_2876 | CSIRO_4019 | CSIRO_2876 | CSIRO_4019 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Phosphoserine phosphatase. | 0.682 |
| CSIRO_2876 | cysS | CSIRO_2876 | CSIRO_2459 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.740 |
| CSIRO_2876 | glyA | CSIRO_2876 | CSIRO_3297 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.729 |
| CSIRO_2876 | metZ | CSIRO_2876 | CSIRO_1266 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | O-acetylhomoserine sulfhydrylase/ O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.936 |
| CSIRO_3008 | CSIRO_1448 | CSIRO_3008 | CSIRO_1448 | Cysteine synthase B. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.874 |
| CSIRO_3008 | CSIRO_2876 | CSIRO_3008 | CSIRO_2876 | Cysteine synthase B. | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.805 |
| CSIRO_3008 | CSIRO_3597 | CSIRO_3008 | CSIRO_3597 | Cysteine synthase B. | Serine acetyltransferase. | 0.979 |
| CSIRO_3008 | CSIRO_3945 | CSIRO_3008 | CSIRO_3945 | Cysteine synthase B. | Serine--glyoxylate aminotransferase. | 0.680 |