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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (952 aa)    
Predicted Functional Partners:
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.996
folD
Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.964
folD-2
Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.964
ADV66163.1
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027: IPR004099: IPR006258; KEGG: dge:Dgeo_2323 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Dihydrolipoyl dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase.
  
 0.958
ADV68422.1
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027: IPR004099: IPR006258; KEGG: ddr:Deide_20540 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Dihydrolipoyl dehydrogenase; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase.
  
 0.958
ADV68307.1
COGs: COG2008 Threonine aldolase; InterPro IPR001597; KEGG: ddr:Deide_09290 putative threonine aldolase; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase; PRIAM: Threonine aldolase; SPTR: Putative Threonine aldolase; PFAM: Beta-eliminating lyase.
    
 0.955
purD
COGs: COG0151 Phosphoribosylamine-glycine ligase; HAMAP: Phosphoribosylglycinamide synthetase; InterPro IPR020562: IPR020561: IPR020560: IPR000115; KEGG: dge:Dgeo_1347 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, [...]
  
  
 0.954
ADV66314.1
Pyridoxal phosphate-dependent acyltransferase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR010962: IPR004839; KEGG: dge:Dgeo_0057 pyridoxal phosphate-dependent acyltransferase, putative; PFAM: Aminotransferase, class I/classII; PRIAM: Glycine C-acetyltransferase; SPTR: 7-keto-8-aminopelargonate synthetase-like enzyme; TIGRFAM: Pyridoxal phosphate-dependent acyltransferase, putative; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase; pyridoxal phosphate-dependent acyltransferase, putative.
  
 
 0.945
Your Current Organism:
Deinococcus maricopensis
NCBI taxonomy Id: 709986
Other names: D. maricopensis DSM 21211, Deinococcus maricopensis DSM 21211, Deinococcus maricopensis LB-34, Deinococcus maricopensis str. DSM 21211, Deinococcus maricopensis strain DSM 21211
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