node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADV65710.1 | ADV67194.1 | Deima_0046 | Deima_1545 | Putative transcriptional regulator, GntR family; COGs: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; InterPro IPR004839; KEGG: dge:Dgeo_2084 aminotransferase, class I and II; PFAM: Aminotransferase, class I/classII; PRIAM: Kynurenine--oxoglutarate transaminase; SPTR: Aminotransferase; PFAM: Aminotransferase class I and II. | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | 0.912 |
ADV67003.1 | ADV67194.1 | Deima_1353 | Deima_1545 | COGs: COG0066 3-isopropylmalate dehydratase small subunit; InterPro IPR011827: IPR000573; KEGG: dge:Dgeo_1154 3-isopropylmalate dehydratase small subunit; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: Lysine biosynthesis protein, homoaconitate hydratase; TIGRFAM: 3-isopropylmalate dehydratase, small subunit, subgroup; PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | 0.984 |
ADV67003.1 | ilvC | Deima_1353 | Deima_1512 | COGs: COG0066 3-isopropylmalate dehydratase small subunit; InterPro IPR011827: IPR000573; KEGG: dge:Dgeo_1154 3-isopropylmalate dehydratase small subunit; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: Lysine biosynthesis protein, homoaconitate hydratase; TIGRFAM: 3-isopropylmalate dehydratase, small subunit, subgroup; PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.824 |
ADV67003.1 | ilvD | Deima_1353 | Deima_1505 | COGs: COG0066 3-isopropylmalate dehydratase small subunit; InterPro IPR011827: IPR000573; KEGG: dge:Dgeo_1154 3-isopropylmalate dehydratase small subunit; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: Lysine biosynthesis protein, homoaconitate hydratase; TIGRFAM: 3-isopropylmalate dehydratase, small subunit, subgroup; PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404: IPR000581; KEGG: sti:Sthe_1518 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase 1; TIGRFAM: Dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.760 |
ADV67003.1 | leuA | Deima_1353 | Deima_1510 | COGs: COG0066 3-isopropylmalate dehydratase small subunit; InterPro IPR011827: IPR000573; KEGG: dge:Dgeo_1154 3-isopropylmalate dehydratase small subunit; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: Lysine biosynthesis protein, homoaconitate hydratase; TIGRFAM: 3-isopropylmalate dehydratase, small subunit, subgroup; PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.833 |
ADV67003.1 | leuC | Deima_1353 | Deima_1355 | COGs: COG0066 3-isopropylmalate dehydratase small subunit; InterPro IPR011827: IPR000573; KEGG: dge:Dgeo_1154 3-isopropylmalate dehydratase small subunit; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: Lysine biosynthesis protein, homoaconitate hydratase; TIGRFAM: 3-isopropylmalate dehydratase, small subunit, subgroup; PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.999 |
ADV67003.1 | leuC-2 | Deima_1353 | Deima_1518 | COGs: COG0066 3-isopropylmalate dehydratase small subunit; InterPro IPR011827: IPR000573; KEGG: dge:Dgeo_1154 3-isopropylmalate dehydratase small subunit; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: Lysine biosynthesis protein, homoaconitate hydratase; TIGRFAM: 3-isopropylmalate dehydratase, small subunit, subgroup; PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.965 |
ADV67003.1 | leuD | Deima_1353 | Deima_1516 | COGs: COG0066 3-isopropylmalate dehydratase small subunit; InterPro IPR011827: IPR000573; KEGG: dge:Dgeo_1154 3-isopropylmalate dehydratase small subunit; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: Lysine biosynthesis protein, homoaconitate hydratase; TIGRFAM: 3-isopropylmalate dehydratase, small subunit, subgroup; PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.578 |
ADV67194.1 | ADV65710.1 | Deima_1545 | Deima_0046 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Putative transcriptional regulator, GntR family; COGs: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; InterPro IPR004839; KEGG: dge:Dgeo_2084 aminotransferase, class I and II; PFAM: Aminotransferase, class I/classII; PRIAM: Kynurenine--oxoglutarate transaminase; SPTR: Aminotransferase; PFAM: Aminotransferase class I and II. | 0.912 |
ADV67194.1 | ADV67003.1 | Deima_1545 | Deima_1353 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | COGs: COG0066 3-isopropylmalate dehydratase small subunit; InterPro IPR011827: IPR000573; KEGG: dge:Dgeo_1154 3-isopropylmalate dehydratase small subunit; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: Lysine biosynthesis protein, homoaconitate hydratase; TIGRFAM: 3-isopropylmalate dehydratase, small subunit, subgroup; PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | 0.984 |
ADV67194.1 | ADV67195.1 | Deima_1545 | Deima_1546 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: dge:Dgeo_1457 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase. | 0.762 |
ADV67194.1 | ADV67196.1 | Deima_1545 | Deima_1547 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Protein of unknown function DUF752; COGs: COG4121 conserved hypothetical protein; InterPro IPR008471; KEGG: dge:Dgeo_1456 hypothetical protein; PFAM: Domain of unknown function DUF752; SPTR: Predicted SAM dependent methyltransferase DUF752; PFAM: Protein of unknown function (DUF752). | 0.757 |
ADV67194.1 | ilvC | Deima_1545 | Deima_1512 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.815 |
ADV67194.1 | ilvD | Deima_1545 | Deima_1505 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404: IPR000581; KEGG: sti:Sthe_1518 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase 1; TIGRFAM: Dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.813 |
ADV67194.1 | leuA | Deima_1545 | Deima_1510 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.772 |
ADV67194.1 | leuC | Deima_1545 | Deima_1355 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.990 |
ADV67194.1 | leuC-2 | Deima_1545 | Deima_1518 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.909 |
ADV67194.1 | leuD | Deima_1545 | Deima_1516 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.910 |
ADV67195.1 | ADV67194.1 | Deima_1546 | Deima_1545 | FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: dge:Dgeo_1457 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase. | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: dge:Dgeo_1458 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | 0.762 |
ADV67195.1 | ADV67196.1 | Deima_1546 | Deima_1547 | FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: dge:Dgeo_1457 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase. | Protein of unknown function DUF752; COGs: COG4121 conserved hypothetical protein; InterPro IPR008471; KEGG: dge:Dgeo_1456 hypothetical protein; PFAM: Domain of unknown function DUF752; SPTR: Predicted SAM dependent methyltransferase DUF752; PFAM: Protein of unknown function (DUF752). | 0.888 |