STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (301 aa)    
Predicted Functional Partners:
sucC
Succinyl-CoA ligase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
ADV66950.1
COGs: COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein subunit; InterPro IPR004489; KEGG: dge:Dgeo_0886 succinate dehydrogenase iron-sulfur subunit; PRIAM: Succinate dehydrogenase; SPTR: Succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: Succinate dehydrogenase/fumarate reductase iron-sulphur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein.
 
 0.990
ADV66951.1
COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR011281: IPR014006: IPR003953: IPR004112; KEGG: ddr:Deide_12450 succinate dehydrogenase flavoprotein subunit; PFAM: Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal; Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal; PRIAM: Succinate dehydrogenase (ubiquinone); SPTR: Putative Succinate dehydrogenase, flavoprotein subunit; TIGRFAM: Succinate dehydrogenase, flavoprotein subunit; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; PFAM: domain; FAD b [...]
 
 0.990
ADV66953.1
InterPro IPR014314; KEGG: dge:Dgeo_0889 succinate dehydrogenase, cytochrome b subunit; SPTR: Succinate dehydrogenase, cytochrome b subunit; TIGRFAM: Succinate dehydrogenase, cytochrome b556 subunit; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit.
  
 
 0.981
ADV68419.1
2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.968
ADV68418.1
COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR001017: IPR005475: IPR011603; KEGG: dge:Dgeo_0140 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase-like, pyrimidine-binding domain; Dehydrogenase, E1 component; PRIAM: Oxoglutarate dehydrogenase (succinyl-transferring); SMART: Transketolase-like, pyrimidine-binding domain; SPTR: 2-oxoglutarate dehydrogenase, E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component; PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 [...]
 
 0.961
ADV66952.1
COGs: COG2142 Succinate dehydrogenase hydrophobic anchor subunit; InterPro IPR000701; KEGG: dge:Dgeo_0888 succinate dehydrogenase, cytochrome b subunit; PFAM: Succinate dehydrogenase/Fumarate reductase, transmembrane subunit; SPTR: Succinate dehydrogenase, cytochrome b subunit; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit.
  
 
 0.948
ADV67681.1
COGs: COG1884 Methylmalonyl-CoA mutase N-terminal domain/subunit; InterPro IPR006099: IPR006158: IPR006098: IPR006159; KEGG: dge:Dgeo_1320 methylmalonyl-CoA mutase; PFAM: Methylmalonyl-CoA mutase, alpha/beta chain, catalytic; Cobalamin (vitamin B12)-binding; PRIAM: Methylmalonyl-CoA mutase; SPTR: Methylmalonyl-CoA mutase, beta subunit; TIGRFAM: Methylmalonyl-CoA mutase, alpha chain, catalytic; Methylmalonyl-CoA mutase, C-terminal; PFAM: Methylmalonyl-CoA mutase; B12 binding domain; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain; methylmalonyl-CoA mutase, heterodimeric type, beta c [...]
    
 0.943
ADV66161.1
Dihydrolipoyllysine-residue acetyltransferase; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089: IPR004167: IPR001078; KEGG: dge:Dgeo_2341 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; E3 binding; PRIAM: Dihydrolipoyllysine-residue acetyltransferase; SPTR: Dihydrolipoamide acyltransferase, (E2) component; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme.
  
 0.924
ADV66647.1
COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089: IPR004167: IPR001078: IPR006256; KEGG: ddr:Deide_03170 putative dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, (E2), (dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex); PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; E3 binding; PRIAM: Dihydrolipoyllysine-residue acetyltransferase; SPTR: Putative Dihydrolipoyllysine-residue acetyltransferase comp [...]
  
 0.924
Your Current Organism:
Deinococcus maricopensis
NCBI taxonomy Id: 709986
Other names: D. maricopensis DSM 21211, Deinococcus maricopensis DSM 21211, Deinococcus maricopensis LB-34, Deinococcus maricopensis str. DSM 21211, Deinococcus maricopensis strain DSM 21211
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