STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEV72634.1PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region. (359 aa)    
Predicted Functional Partners:
AEV72651.1
DNA polymerase LigD, polymerase domain protein; PFAM: Eukaryotic and archaeal DNA primase small subunit; TIGRFAM: DNA ligase D; DNA polymerase LigD, polymerase domain.
   
 0.950
AEV73897.1
Putative DNA primase; TIGRFAM: DNA polymerase LigD, polymerase domain.
   
 0.949
AEV72052.1
Putative DNA primase; PFAM: Eukaryotic and archaeal DNA primase small subunit; TIGRFAM: DNA polymerase LigD, polymerase domain.
   
 0.924
AEV72431.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 0.888
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.880
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.833
AEV75570.1
PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain.
 
 0.830
AEV72633.1
2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase; PFAM: FAD binding domain.
     
 0.783
AEV72632.1
Hypothetical protein.
       0.760
AEV71524.1
Helicase family protein; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase.
  
 0.660
Your Current Organism:
Mycolicibacterium rhodesiae NBB3
NCBI taxonomy Id: 710685
Other names: M. rhodesiae NBB3, Mycobacterium rhodesiae NBB3
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.