STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU46573.1KEGG: kra:Krad_0008 hypothetical protein; SPTR: Putative integral membrane protein; PFAM: Transmembrane domain of unknown function (DUF3566). (215 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.911
ADU48569.1
KEGG: kra:Krad_3338 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3052).
  
     0.724
ADU47826.1
KEGG: aau:AAur_2578 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3039).
  
     0.701
ADU46567.1
Protein of unknown function DUF721; COGs: COG5512 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives; InterPro IPR007922; KEGG: kra:Krad_0005 protein of unknown function DUF721; PFAM: protein of unknown function DUF721; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF721).
 
     0.679
whiB-4
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.671
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.613
ADU49022.1
KEGG: kra:Krad_3844 hypothetical protein; SPTR: Putative uncharacterized protein; manually curated; PFAM: Domain of unknown function (DUF1025).
  
     0.599
ADU47282.1
KEGG: ske:Sked_31380 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3027).
  
     0.580
ADU48112.1
KEGG: mkm:Mkms_2155 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: NADPH-dependent FMN reductase.
   
    0.575
ADU49707.1
KEGG: kse:Ksed_06070 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3073).
  
   
 0.572
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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