STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADU46658.1ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; COGs: COG0439 Biotin carboxylase; InterPro IPR003135: IPR011761; KEGG: gau:GAU_1512 hypothetical protein; PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; SPTR: Putative uncharacterized protein; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain. (407 aa)    
Predicted Functional Partners:
carA
COGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR017926: IPR001317: IPR011702: IPR006220: IPR 002474: IPR000991: IPR006274; KEGG: sma:SAV_6866 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; PRIAM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing); SPTR: Carbamoyl-phosphate synthase, small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase [...]
  
 
 0.966
ADU46659.1
Hypothetical protein; KEGG: rle:pRL90043 putative transmembrane transport protein; SPTR: Putative transmembrane transport protein; manually curated; PFAM: Peptidase family S51; Belongs to the peptidase S51 family.
 
     0.952
ADU46660.1
Esterase; COGs: COG2382 Enterochelin esterase; InterPro IPR000801; KEGG: ppd:Ppro_1478 putative esterase; PFAM: esterase; SPTR: Putative esterase; PFAM: Domain of unknown function (DUF3327); Putative esterase.
 
     0.952
ADU46661.1
COGs: COG4947 conserved hypothetical protein; KEGG: dfe:Dfer_4768 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.924
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.857
ADU48118.1
Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR017927: IPR006058: IPR019480; KEGG: ace:Acel_1297 dihydroorotate oxidase B, electron transfer subunit; PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; SPTR: Dihydroorotate dehydrogenase electron transfer subunit; PFAM: Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B.
  
 
 0.845
pyrB
COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterPro IPR002082: IPR006130: IPR006132: IPR006131; KEGG: kse:Ksed_12660 aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; SPTR: Aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: aspartate carbamoyltransferase; Belongs to the asparta [...]
  
  
 0.839
ADU48120.1
COGs: COG0284 Orotidine-5'-phosphate decarboxylase; InterPro IPR018089: IPR001754: IPR011995; KEGG: kra:Krad_3000 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; PRIAM: Orotidine-5'-phosphate decarboxylase; SPTR: Orotidine 5'-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 2; Belongs to the OMP decarboxylase family. Type 2 subfamily.
  
  
 0.839
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
  
 
 0.837
pyrR
Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
  
  
 0.816
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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