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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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ADU46704.1Transcriptional regulator, LuxR family; COGs: COG3899 ATPase; InterPro IPR000792; KEGG: nca:Noca_4382 regulatory protein, LuxR; PFAM: regulatory protein LuxR; SMART: regulatory protein LuxR; SPTR: Putative LuxR-family transcriptional regulator; PFAM: Bacterial regulatory proteins, luxR family. (985 aa)    
Predicted Functional Partners:
ADU49815.1
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003018: IPR011712: IPR003594; KEGG: saq:Sare_1529 GAF sensor signal transduction histidine kinase; PFAM: GAF domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: GAF domain protein; SPTR: GAF sensor signal transduction histidine kinase; PFAM: Histidine kinase; GAF domain.
 
 
 0.736
ADU49308.1
Histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR000595: IPR003594: IPR005467: IPR004358; KEGG: rha:RHA1_ro04003 sensor kinase, two-component system; PFAM: ATP-binding region ATPase domain protein; cyclic nucleotide-binding; SMART: ATP-binding region ATPase domain protein; cyclic nucleotide-binding; SPTR: Histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
 
 0.709
ADU46986.1
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467: IPR001789: IPR000014: IPR000700: IPR 005561: IPR013656: IPR003661: IPR003594: IPR013767: IPR004358; KEGG: ami:Amir_3954 multi-sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; response regulator receiver; PAS fold domain protein; ANTAR domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Multi [...]
  
 
 0.647
ADU46705.1
KEGG: nve:NEMVE_v1g242007 hypothetical protein; SPTR: Predicted protein.
       0.574
ADU47048.1
InterPro IPR000169; KEGG: tcu:Tcur_1854 Flp pilus assembly protein CpaB; SPTR: Putative uncharacterized protein; TIGRFAM: Flp pilus assembly protein CpaB.
 
    0.566
ADU46647.1
Aminoglycoside phosphotransferase; COGs: COG0510 choline kinase involved in LPS biosynthesis; InterPro IPR002575; KEGG: scb:SCAB_38761 putative phosphotransferase; PFAM: aminoglycoside phosphotransferase; SPTR: Putative phosphotransferase; PFAM: Phosphotransferase enzyme family.
  
     0.550
ADU48999.1
KEGG: sro:Sros_2595 hypothetical protein; SPTR: Putative uncharacterized protein.
  
    0.538
ADU49309.1
Response regulator receiver protein; COGs: COG0492 Thioredoxin reductase; InterPro IPR001789: IPR000103: IPR013027; KEGG: rer:RER_40230 two-component system thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver modulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Response regulator receiver domain.
 
 
 0.528
ADU49764.1
COGs: COG3629 DNA-binding transcriptional activator of the SARP family; InterProIPR019775: IPR019782: IPR017986: IPR001680: IPR 001867: IPR005158; KEGG: nml:Namu_2911 transcriptional regulator, SARP family; PFAM: transcriptional activator domain; transcriptional regulator domain-containing protein; SPTR: Transcriptional regulator, SARP family; PFAM: Bacterial transcriptional activator domain; Transcriptional regulatory protein, C terminal.
 
  
 0.508
ADU47303.1
Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001932: IPR007895: IPR010822: IPR003594; KEGG: gob:Gobs_0116 multi-sensor signal transduction histidine kinase; PFAM: Stage II sporulation protein E; MASE1 domain protein; ATP-binding region ATPase domain protein; SMART: protein phosphatase 2C domain protein; SPTR: Multi-sensor signal transduction histidine kinase; PFAM: Stage II sporulation protein E (SpoIIE); MASE1.
 
  
 0.488
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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