Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
patHistidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (372 aa)    
Predicted Functional Partners:
hisB
COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807: IPR020565; KEGG: bcv:Bcav_2392 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase.
 
 0.996
ADU48348.1
COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099: IPR002912; KEGG: kra:Krad_3118 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; amino acid-binding ACT domain protein; SPTR: Prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; ACT domain.
  
 
 0.966
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.958
ADU47830.1
COGs: COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins; InterPro IPR005956: IPR004360; KEGG: rha:RHA1_ro03170 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; PRIAM: 4-hydroxyphenylpyruvate dioxygenase; SPTR: Putative 4-hydroxyphenylpyruvate dioxygenase; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase.
    
 0.918
pheA
COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR002912: IPR018528; KEGG: ach:Achl_0282 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; PFAM: Prephenate dehydratase.
  
 
 0.917
hisC
COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR005861: IPR001917: IPR004839; KEGG: sna:Snas_3996 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 
0.917
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.911
ADU49041.1
COGs: COG0483 fructose-1 6-bisphosphatase of inositol monophosphatase family; InterPro IPR011809: IPR000760: IPR020583; KEGG: aau:AAur_2645 histidinol-phosphate phosphatase; PFAM: inositol monophosphatase; SPTR: Putative inositol monophosphatase; TIGRFAM: histidinol-phosphate phosphatase; PFAM: Inositol monophosphatase family; TIGRFAM: histidinol-phosphate phosphatase HisN, inositol monophosphatase family.
  
 
 0.906
katG
Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily.
     
 0.905
tpl
Tyrosine phenol-lyase; COGs: COG3033 Tryptophanase; InterPro IPR001597: IPR011166: IPR013441; KEGG: sth:STH2842 tyrosine phenol-lyase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; PRIAM: Tyrosine phenol-lyase; SPTR: Tyrosine phenol-lyase; TIGRFAM: tyrosine phenol-lyase; PFAM: Beta-eliminating lyase; TIGRFAM: tyrosine phenol-lyase.
     
  0.900
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.