STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dcddCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (192 aa)    
Predicted Functional Partners:
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 
 0.927
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
 
 0.926
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
    
 0.924
ADU46837.1
Alpha/beta hydrolase fold protein; InterPro IPR000073; KEGG: sco:SCO0635 hypothetical protein; PFAM: alpha/beta hydrolase fold; SPTR: Putative uncharacterized protein; PFAM: alpha/beta hydrolase fold.
       0.697
ADU47686.1
dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
   
    0.565
ADU46838.1
ABC transporter related protein; COGs: COG1125 ABC-type proline/glycine betaine transport systems ATPase components; InterPro IPR003439: IPR003593: IPR017871; KEGG: kse:Ksed_26260 glycine betaine/L-proline transport ATP binding subunit; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: Putative ABC transporter ATP-binding subunit; PFAM: ABC transporter; TIGRFAM: glycine betaine/L-proline transport ATP binding subunit.
       0.564
ADU46839.1
COGs: COG1174 ABC-type proline/glycine betaine transport systems permease component; InterPro IPR000515; KEGG: nml:Namu_1405 binding-protein-dependent transport systems inner membrane component; PFAM: binding-protein-dependent transport systems inner membrane component; SPTR: ABC-type glycine betaine transport, permease protein; PFAM: Binding-protein-dependent transport system inner membrane component.
       0.564
ADU46840.1
COGs: COG1174 ABC-type proline/glycine betaine transport systems permease component; InterPro IPR000515; KEGG: kse:Ksed_26240 ABC-type proline/glycine betaine transport system, permease component; PFAM: binding-protein-dependent transport systems inner membrane component; SPTR: ABC transporter-associated permease; PFAM: Binding-protein-dependent transport system inner membrane component.
       0.564
ADU46841.1
COGs: COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein); InterPro IPR007210; KEGG: nml:Namu_1403 substrate-binding region of ABC-type glycine betaine transport system; PFAM: Substrate-binding region of ABC-type glycine betaine transport system; SPTR: ABC-type glycine betaine transport, substrate-binding protein; PFAM: Substrate binding domain of ABC-type glycine betaine transport system.
       0.559
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
  
 0.516
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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