STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU46851.1SPFH domain, Band 7 family protein; COGs: COG0330 Membrane protease subunits stomatin/prohibitin homologs; InterPro IPR001107: IPR001972; KEGG: pac:PPA1973 stomatin/prohibitin-like protein; PFAM: band 7 protein; SMART: band 7 protein; SPTR: Putative uncharacterized protein; PFAM: SPFH domain / Band 7 family. (265 aa)    
Predicted Functional Partners:
ftsH
Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.971
ADU46852.1
KEGG: mpa:MAP3182 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.862
ADU46853.1
Nitric oxide reductase, NorZ apoprotein; COGs: COG3256 Nitric oxide reductase large subunit; InterPro IPR000883; KEGG: mjl:Mjls_1539 nitric-oxide reductase subunit B; PFAM: cytochrome c oxidase subunit I; SPTR: Nitric oxide reductase; PFAM: Cytochrome C and Quinol oxidase polypeptide I.
 
     0.838
ADU46620.1
Rhomboid family protein; COGs: COG0705 membrane protein; InterPro IPR002610; KEGG: xce:Xcel_0012 rhomboid family protein; PFAM: Rhomboid family protein; SPTR: Rhomboid family protein; PFAM: Rhomboid family.
   
 0.806
ADU48245.1
Protein of unknown function DUF107; COGs: COG1585 Membrane protein implicated in regulation of membrane protease activity; InterPro IPR002810; KEGG: kra:Krad_3088 protein of unknown function DUF107; PFAM: protein of unknown function DUF107; SPTR: Putative integral membrane protein; PFAM: NfeD-like.
 
  
 0.598
arc
AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
   
 
 0.581
ADU47824.1
Protein of unknown function DUF179; COGs: COG1678 Putative transcriptional regulator protein; InterPro IPR003774; KEGG: kra:Krad_3774 hypothetical protein; PFAM: protein of unknown function DUF179; SPTR: UPF0301 protein Krad_3774; PFAM: Uncharacterized ACR, COG1678.
   
    0.557
ADU49042.1
Peptidase M16 domain protein; COGs: COG0612 Zn-dependent peptidase; InterPro IPR011765: IPR007863; KEGG: kse:Ksed_19020 predicted Zn-dependent peptidase; PFAM: peptidase M16 domain protein; SPTR: Putative protease; PFAM: Peptidase M16 inactive domain; Insulinase (Peptidase family M16).
  
 0.548
ADU49043.1
Peptidase M16 domain protein; COGs: COG0612 Zn-dependent peptidase; InterPro IPR011765: IPR007863; KEGG: kfl:Kfla_5236 peptidase M16 domain protein; PFAM: peptidase M16 domain protein; SPTR: Zinc protease; PFAM: Peptidase M16 inactive domain; Insulinase (Peptidase family M16).
  
 0.548
ADU48268.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
   
  0.528
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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